| 简伟明,宋 伟,刘海涛,李 晨,吴利平,张 华.膀胱尿路上皮肿瘤合并2型糖尿病患者临床和病理特点的比较性研究[J].,2020,(3):479-483 |
| 膀胱尿路上皮肿瘤合并2型糖尿病患者临床和病理特点的比较性研究 |
| The Comparative Research of Clinical and Pathological Features about Urothelial Bladder Neoplasms with Type 2 Diabetes mMllitus |
| 投稿时间：2019-06-26 修订日期：2019-07-21 |
| DOI：10.13241/j.cnki.pmb.2020.03.016 |
| 中文关键词: 膀胱肿瘤 2型糖尿病 临床 病理 比较研究 |
| 英文关键词: Bladder Neoplasms Type 2 diabetes mellitus Pathology Clinical Comparative Study |
| 基金项目:国家自然科学基金项目（81370928）；陕西省社会发展科技攻关项目（2015SF095）；空军军医大学第一附属医院学科助推计划项目（XJZT18ML79） |
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| 中文摘要: |
| 摘要 目的：对比分析膀胱尿路上皮肿瘤合并2型糖尿病患者的临床和病理特点，为临床诊疗工作提供一定的参考。方法：回顾性分析2015年1月至2019年2月于我院泌尿外科手术治疗且经病理确诊为原发性膀胱尿路上皮肿瘤的患者资料，合并2型糖尿病的膀胱肿瘤患者59例设为糖尿病组（T2DM组），根据性别和年龄按照1:2的比例匹配同时期未合并2型糖尿病的膀胱肿瘤118例患者为非糖尿病组（NT2DM组），比较两组患者的临床特征和病理特点。结果：T2DM组的高血压患者比例和血肌酐值高于NT2DM组（P<0.05），而在教育程度、吸烟、饮酒、BMI、前列腺增生、泌尿系感染、血常规、肝功、尿常规、肿瘤大小、数量方面无明显统计学差异（P>0.05）。T2DM组和NT2DM组在膀胱尿路上皮肿瘤良恶性分类、肿瘤数量、肿瘤大小的构成比上无明显统计学差异（P>0.05）；然而，对膀胱恶性肿瘤患者进行亚组分析显示，T2DM亚组中肌层浸润性癌的比例和高级别癌的比例明显高于NT2DM亚组，差异有统计学意义（P<0.05）。结论：2型糖尿病可能使膀胱癌的病理分级和分期更高，导致患者预后更差，临床上应更加关注膀胱恶性肿瘤合并2型糖尿病患者的诊治。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the clinical and pathological characteristics of urothelial bladder neoplasms with type 2 diabetes mellitus in order to provide some references for clinical diagnosis and treatment. Methods: The data of patients diagnosed with urothelial bladder neoplasms by pathology and underwent surgery in urology department of our hospital from January 2015 to February 2019 were analyzed retrospectively. Fifty-nine patients with bladder neoplasms with type 2 diabetes mellitus were divided into type 2 diabetes mellitus group (T2DM group). According to sex and age, 118 patients with bladder neoplasms without type 2 diabetes mellitus in the same period were matched in non-type 2 diabetes mellitus group (NT2DM group) according to the ratio of 1:2. The clinical and pathological characteristics of patients in the two groups were compared. Results: The proportion of hypertensive patients and serum creatinine in T2DM group were higher than those in NT2DM group (P<0.05), but there were no significant differences between the two groups in education level, smoking, drinking, BMI, BPH, urinary tract infection, routine blood tests, liver laboratory tests, routine urinary tests, tumor size and number(P>0.05). There was no significant differences in the proportion of benign and malignant urothelial bladder tumors, the number of tumors and the size of tumors between T2DM group and NT2DM group(P>0.05). However, subgroup analysis of malignant bladder neoplasms patients showed that the proportion of muscle-invasive bladder cancer and high-grade cancer in T2DM subgroup was significantly higher than that in NT2DM subgroup(P<0.05). Conclusion: Type 2 diabetes mellitus may lead to a higher pathological grade and stage of bladder cancer. More attention should be paid to the diagnosis and treatment of bladder cancer with type 2 diabetes mellitus. |
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