文章摘要
冯禹楠,王鑫睿,廉 坤,杨茂森,赵 帅,陈根锐,高好考,汪 钦.不同亚型脂联素与非酒精性脂肪性肝病的关系[J].,2020,(3):428-433
不同亚型脂联素与非酒精性脂肪性肝病的关系
The Correlation between Different Adiponectin Isoforms with Nonalcoholic Fatty Liver Disease
投稿时间:2019-05-23  修订日期:2019-06-17
DOI:10.13241/j.cnki.pmb.2020.03.006
中文关键词: 非酒精性脂肪性肝病  高分子量脂联素  中分子量脂联素  低分子量脂联素
英文关键词: Nonalcoholic fatty liver disease (NAFLD)  High-molecular-weight adiponectin (HMW APN)  Medium-molecular-weight adiponectin (MMW APN)  Low-molecular-weight adiponectin (LMW APN)
基金项目:陕西省科学技术研究发展计划项目(2016SF-034);陕西省重点研发计划一般项目-社会发展领域(2018SF-153);国家自然科学基金青年科学基金项目(81500272);国家自然科学基金面上项目(81670229,81570210)
作者单位E-mail
冯禹楠 空军军医大学基础医学院学员队 陕西 西安 710032 1586280894@qq.com 
王鑫睿 空军军医大学基础医学院学员队 陕西 西安 710032  
廉 坤 空军军医大学西京医院心血管内科 陕西 西安 710032  
杨茂森 空军军医大学基础医学院学员队 陕西 西安 710032  
赵 帅 空军军医大学基础医学院学员队 陕西 西安 710032  
陈根锐 空军军医大学西京医院心血管内科 陕西 西安 710032  
高好考 空军军医大学西京医院心血管内科 陕西 西安 710032  
汪 钦 空军军医大学药学院药物基因组学教研室 陕西 西安 710032  
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中文摘要:
      摘要 目的:探究总脂联素(total adiponectin,total APN)和高分子量脂联素(high-molecular-weight adiponectin,HMW APN)与非酒精性脂肪性肝病(Nonalcoholic Fatty Liver Disease,NAFLD)的关系。方法:连续纳入50名男性健康男性及50名非酒精性脂肪性肝病男性患者,收集患者临床资料及其他临床生化数据,通过ELISA法检测总脂联素、支链氨基酸及可溶性晚期糖基化终末产物含量,Western blot法测定高分子量、中分子量和低分子量脂联素水平,进一步分析其相关性。结果:与对照组的健康受试者相比,NAFLD患者的总脂联素和三种不同形式的脂联素水平均显著降低。在NAFLD患者中,总脂联素与身高(R=-0.270, P=0.032)和羧甲基赖氨酸(R=-0.259, P=0.040)显著负相关;高分子量脂联素与空腹血糖(R=0.350, P=0.016)显著正相关,与丙氨酸氨基转移酶(R=-0.321, P=0.029)和天门冬氨酸氨基转移酶(R=-0.295, P=0.045)显著负相关。结论:总脂联素和三种不同形式的脂联素水平均与NAFLD呈显著负相关。
英文摘要:
      ABSTRACT Objective: To investigate the correlation between total adiponectin (total APN) and high-molecular-weight adiponectin (HMW APN) with nonalcoholic fatty liver disease(NAFLD). Methods: A total of 50 healthy males and 50 male patients with NAFLD were included in the study. Their clinical biochemical characteristics were measured and collected. Total adiponectin, branched chain amino acid (BCAAs) and soluble receptor for advanced glycation end product (sRAGE) were measured by ELISA. The variation of high-molecular-weight, medium-molecular-weight and low-molecular-weight adiponectin levels were determined by Western blot in NAFLD patients. Then, the correlation among the characteristics was further analyzed. Results: When compared with healthy subjects in control group, significantly decreased levels of total adiponectin and three adiponectin isoforms were found in NAFLD patients. In NAFLD patients, height (R=-0.270, P=0.032) and N-epsilon carboxymethyl lysine (CML) (R=-0.259, P=0.040) were significantly negatively correlated with total adiponectin; HMW adiponectin was significantly positively associated with fasting plasma glucose (FPG) (R=0.350, P=0.016), and negatively associated with ALT (R=-0.321, P=0.029) and AST (R=-0.295, P=0.045) respectively. Conclusion: The levels of total adiponectin and three adiponectin isoforms are in significantly negative correlation with NAFLD.
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