| 吴新婷,卞伟妮,郑玲芳,何 薇,贾 南,王 珊.促红细胞生成素对脑损伤早产儿NBNA评分、肝肾功能以及脑干听觉诱发电位的影响[J].,2020,(2):349-352 |
| 促红细胞生成素对脑损伤早产儿NBNA评分、肝肾功能以及脑干听觉诱发电位的影响 |
| Effect of Erythropoietin on NBNA Score, Liver and Kidney Function and Brainstem Auditory Evoked Potential in Premature Infants with Brain Injury |
| 投稿时间：2019-04-26 修订日期：2019-05-22 |
| DOI：10.13241/j.cnki.pmb.2020.02.031 |
| 中文关键词: 促红细胞生成素 脑损伤 早产儿 新生儿神经行为测定评分 肝功能 肾功能 脑干听觉诱发电位 |
| 英文关键词: Erythropoietin Brain injury Premature infants Neonatal neurobehavioral assessment score Liver function Kidney function Brainstem auditory evoked potential |
| 基金项目:陕西省科技计划项目（2014089352） |
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| 摘要 目的：探讨促红细胞生成素（EPO）对脑损伤早产儿新生儿神经行为测定（NBNA）评分、肝肾功能以及脑干听觉诱发电位的影响。方法：选取2015年2月~2018年7月期间我院收治的脑损伤早产儿117例，将上述研究对象根据随机数字表法将其分为对照组（n=58）和观察组（n=59），对照组患儿给予常规对症治疗，观察组在对照组的基础上联合EPO治疗，比较两组NBNA评分、肝肾功能以及脑干听觉诱发电位，记录两组患儿治疗期间并发症发生情况。结果：观察组纠正胎龄40周时NBNA评分高于对照组（P<0.05）。两组患儿治疗后峰间期（Ⅰ~Ⅲ波、Ⅲ~Ⅳ波、Ⅰ~Ⅳ波）、潜伏期（Ⅰ波、Ⅲ波、Ⅳ波）均较治疗前降低，且观察组低于对照组（P<0.05）。两组患儿治疗前、后尿素氮（BUN）、肌酐（Cr）、血清谷丙转氨酶（SGPT）、总胆红素（TBIL）比较差异均无统计学意义（P>0.05）。两组患儿动脉导管未闭、新生儿败血症发生率比较差异无统计学意义（P>0.05），而观察组支气管肺发育不良、颅内出血、脑干听觉诱发电位异常等发生率低于对照组（P<0.05）。结论：EPO对脑损伤早产儿具有一定的神经保护作用，能够有效保护受损神经细胞与听觉神经通路，降低脑损伤并发症的发生率，且不影响患儿的肝肾功能。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of erythropoietin (EPO) on neonatal neurobehavioral assessment (NBNA) score,liver and kidney function and brainstem auditory evoked potential in premature infants with brain injury. Methods: 117 premature infants with brain injury who were admitted to our hospital from February 2015 to July 2018 were selected, and the subjects were divided into control group (n=58) and observation group (n=59) according to the digital table method. The control group was given routine symptomatic treatment. The observation group was treated with EPO on the basis of the control group. The NBNA score,liver and kidney function and brainstem auditory evoked potentials were compared between the two groups, and the complications of the two groups were recorded during the treatment. Results: The NBNA score of the observation group at 40 weeks of corrected gestational age was higher than that of the control group (P<0.05). The peak interval (I~III wave, III~IV wave, I~IV wave) and incubation period (I wave, III wave, IV wave) of the two groups after treatment were lower than those before treatment, and those of the observation group were lower than those of the control group (P<0.05). There were no significant differences in urea nitrogen (BUN), creatinine (Cr), serum glutamic-pyruvic transaminase(SGPT) and total bilirubin (TBIL) between the two groups before and after treatment (P>0.05). There were no significant differences in the incidence of patent ductus arteriosus and neonatal sepsis between the two groups (P>0.05), while the incidence of bronchopulmonary dysplasia, intracranial hemorrhage and abnormal brainstem auditory evoked potential in the observation group were lower than those in the control group (P<0.05). Conclusion: EPO has a certain neuroprotective effect on premature infants with brain injury.It can effectively protect the injured nerve cells and auditory nerve pathways,reduce the incidence of complications of brain injury, and it do not affect the liver and kidney function of the infants. |
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