| 宋 丹,路旭宏,胡向红,冯 奥,刘 丹,吕 薇,李 程.脂溶性维生素A、D、E与妊娠期糖尿病的相关性分析[J].,2020,(1):115-117 |
| 脂溶性维生素A、D、E与妊娠期糖尿病的相关性分析 |
| Correlative analysis between Fat-soluble vitamins A, D and E and Gestational Diabetes |
| 投稿时间：2019-03-28 修订日期：2019-04-23 |
| DOI：10.13241/j.cnki.pmb.2020.01.025 |
| 中文关键词: 妊娠期糖尿病 维生素A 25-羟基维生素D 维生素E |
| 英文关键词: Gestational diabetes mellitus Vitamin A 25-hydroxyvitamin D Vitamin E |
| 基金项目:国家卫生和计划生育委员会医药卫生科技发展中心项目(W2015CAE127) |
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| 中文摘要: |
| 摘要 目的：探讨妊娠期糖尿病(gestational diabetes mellitus，GDM)孕妇血清中维生素A、25-羟基维生素D、维生素E的水平及其临床意义。方法：选取在大连大学附属中山医院就诊并诊断为GDM的孕妇1000例为实验组；另选取无GDM孕妇1000例为对照组。采用反向高频液相色谱荧光法(high-performance liquid chromatography，HPLC)测定其血清维生素A、E水平；高效液相色谱液相色谱串联质谱法(high-performance liquid chromatography tandem mass spectrometer，HPLC-AS/MS)测定血清25-羟基维生素D水平。结果：GDM孕妇血清中维生素A水平与无GDM孕妇比较差异无统计学意义(P>0.05)；GDM孕妇血清25-羟基维生素D水平明显低于对照组(P<0.05)；GDM孕妇血清维生素E水平明显高于对照组(P<0.05)。GDM孕妇血清25-羟基维生素D水平与血清维生素E水平呈显著负相关(r=-0.351，P<0.05)。结论：GDM孕妇血清25-羟基维生素D水平低，维生素E水平高，且两者有一定相关性，可能共同参与了GDM的发生。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the expression levels and clinical significance of vitamin A, 25-hydroxyvitamin D, vitamin E in pregnant women with gestational diabetes mellitus. Methods: One hundred patients with GDM diagnosed in Zhongshan Hospital Affiliated to Dalian University were selected as experimental group; 100 non-GDM patients were selected as control group. High-performance liquid chromatography (HPLC) was used to determine vitamin A and E levels; high-performance liquid chromatography tandem mass spectrometer(HPLC-AS/MS) was used to determine 25-hydroxyvitamin D levels. Results: There was no significant difference in serum vitamin A levels between GDM patients and non-GDM patients (P>0.05); the serum 25-hydroxyvitamin D levels in GDM patients were significantly lower than those in the control group (P<0.05); the serum vitamin E levels in GDM patients were significantly higher than those in the control group (P<0.05). The serum level of 25-hydroxyvitamin D in patients with GDM was negatively correlated with the expression of vitamin E (r=-0.351, P<0.05). Conclusion: The level of 25-hydroxyvitamin D in patients with GDM is low, and the level of vitamin E is high, and there is a certain correlation between the two, and they may jointly participate in the development of GDM. |
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