| 孙 林,王海燕,王美仙,王化丽,刘莉娜.多囊卵巢综合征患者胰岛素抵抗和胰岛β细胞分泌功能与氧化应激的相关性研究[J].,2019,19(24):4780-4784 |
| 多囊卵巢综合征患者胰岛素抵抗和胰岛β细胞分泌功能与氧化应激的相关性研究 |
| Pancreatic β Cell Secretory Function and Oxidative Stress with the Insulin Resistance in Patients with Polycystic Ovary Syndrome Correlation |
| 投稿时间：2019-07-23 修订日期：2019-08-17 |
| DOI：10.13241/j.cnki.pmb.2019.24.042 |
| 中文关键词: 多囊卵巢综合征(PCOS) 胰岛素抵抗(IR) 胰岛β细胞分泌功能 氧化应激 |
| 英文关键词: Polycystic ovary syndrome (PCOS) Insulin resistance (IR) Pancreatic β cell secretory function Oxidative stress |
| 基金项目:中华医学会临床医学科研专项基金项目(16020250641)；辽宁省自然科学基金指导计划面上项目(20180550614) |
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| 中文摘要: |
| 摘要 目的：探讨多囊卵巢综合征(PCOS)患者胰岛素抵抗(IR)和胰岛β细胞分泌功能与氧化应激的相关性。方法：选择122名在大连市妇幼保健院生殖保健中心就诊的PCOS患者82例，包括IR组42例和非IR组40例，同期选取单纯因男性因素不育而月经规律、内分泌激素正常的对照组患者40例。检测空腹血糖(FBG)、空腹胰岛素(FINS)水平，测定血清活性氧(ROS)和丙二醛(MDA)含量以评价机体氧化应激，测定血清总抗氧化能力(TAC)和超氧化物歧化酶(SOD)含量评价机体的抗氧化能力，使用稳态模型评价机体的胰岛素抵抗(HOMA-IR)和胰岛β细胞分泌功能(HOMA-β)。结果：PCOS胰岛素抵抗组患者身体质量指数(BMI)、促黄体素(LH)、黄体生成激素/卵泡生成激素(LH/FSH)、睾酮(T)、FBG、FINS和HOMA- IR显著高于非IR和对照组，而HOMA-β显著低于非IR和对照组，差异均有统计学意义(P＜0.05)；PCOS胰岛素抵抗组血清ROS和MDA含量较非IR组和对照组显著升高(P＜0.05)，非IR组ROS含量显著高于对照组(P＜0.05)，而非IR组和对照组MDA含量相比差异无显著性(P＞0.05)；PCOS胰岛素抵抗组血清TAC和SOD含量较非IR组和对照组显著降低(P＜0.05)，而非IR组血清TAC和SOD含量低于对照组，但差异无显著性(P＞0.05)。PCOS患者HOMA-IR与体质指数(BMI)及血清ROS和MDA水平呈正相关P＜0.01)，与血清TAC和SOD活性呈显著负相关(P＜0.05)。结论：氧化应激与PCOS患者胰岛素抵抗密切相关，可能在其胰岛素抵抗发生发展进程中发挥着重要的作用。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between insulin resistance (IR) and pancreatic β cell secretory function and oxidative stress in patients with polycystic ovary syndrome (PCOS). Methods: A total of 122 participants were enrolled in the Reproductive Health Center of the Maternal and Child Health Hospital of Dalian, including 82 patients with PCOS (42 associated with IR and 40 without IR). The control group was 40 patients of the menstrual regularity and normal endocrine hormone were selected due to male factor infertility. The fasting blood glucose (FBG) and fasting insulin (FINS) were measured. The concentration of serum reactive oxygen species (ROS), malondialdehyde (MDA) and the activity of serum superoxide dismutase (SOD) and total antioxidant capacity (TAC) levels in all patients were measured to evaluate oxidative stress in the body. The homeostasis model was used to evaluate the body's insulin resistance (HOMA-IR) and pancreatic β cell secretory function (HOMA-β). Results: The body mass index (BMI), luteinizing hormone (LH), luteinizing hormone (LH/FSH), testosterone (T), FBG, FINS and HOMA-IR were significantly higher in the PCOS with insulin resistance group than those in the non-IR and control groups, while HOMA-β was significantly lower than those of the non-IR and control groups. The ROS and MDA in the PCOS IR group were significantly higher than that in the non-IR group and the control group (P<0.05), and the ROS content in the non-IR group was significantly higher than that in the control group(P<0.05). There was no significant difference in the MDA content between the non-IR group and the control group(P>0.05). The levels of serum TAC and SOD in the PCOS IR group were significantly lower than those in the non-IR group and the control group(P<0.05). The serum levels of TAC and SOD in the group were lower than those in the control group, but no significant difference was found(P>0.05). HOMA-IR in patients with PCOS were positively associated with the body mass index (BMI), serum ROS and MDA levels(P<0.01), and were negatively associated with the serum TAC and SOD activities(P<0.05). Conclusion: Oxidative stress is closely related to the insulin resistance in patients with PCOS, and may play an important role in the development of insulin resistance. |
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