| 朱疆依,朱玉侠,梅 琳,冯 波,郭长存.自体干细胞移植治疗失代偿期肝硬化的疗效及对肝脏储备功能、血清LPS、HGF水平的影响[J].,2019,19(24):4756-4759 |
| 自体干细胞移植治疗失代偿期肝硬化的疗效及对肝脏储备功能、血清LPS、HGF水平的影响 |
| Curative Efficacy of Autologous Stem Cell Transplantation in the Treatment of Decompensated Cirrhosis and Its Effects on the Liver Reserve Function, Serum LPS and HGF Levels |
| 投稿时间：2019-06-23 修订日期：2019-07-18 |
| DOI：10.13241/j.cnki.pmb.2019.24.036 |
| 中文关键词: 自体干细胞移植 失代偿期肝硬化 肝脏储备功能 内毒素 肝细胞生长因子 |
| 英文关键词: Autologous stem cell transplantation Decompensated cirrhosis Liver reserve function Endotoxin Hepatocyte growth factor |
| 基金项目:陕西省社会发展重点项目(2018ZDXM-SF-053) |
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| 中文摘要: |
| 摘要 目的：探讨自体干细胞移植治疗失代偿期肝硬化的疗效及对肝脏储备功能、血清内毒素(LPS)、肝细胞生长因子(HGF)水平的影响。方法：选择2015年9月至2017年9月我院接诊的86例失代偿期肝硬化患者作为本研究对象，通过随机数表法将其分为观察组和对照组，每组43例。对照组给予失代偿期肝硬化常规综合治疗，观察组在对照组基础上进行自体干细胞移植治疗。比较两组治疗前、治疗12周后实验室指标、终末期肝病模型系统评分(MELD)、血清LPS、HGF水平的变化以及不良反应的发生情况。结果：治疗后，两组丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、总胆红素(TBil)水平均明显低于治疗前，白蛋白(ALB)较治疗前显著升高(P＜0.05)，观察组ALT、AST、TBil均明显低于对照组，ALB水平明显高于对照组[(45.60±4.12)U/L vs. (56.84±6.20)U/L，(57.45±5.01)U/L vs. (68.99±6.84)U/L，(36.53±3.45)g/L vs. (30.42±2.89)g/L，(50.23±4.83)μmol/L vs. (62.30±6.76) μmol/L](P＜0.05)；治疗后，两组MELD评分较治疗前显著降低(P＜0.05)，观察组MELD评分明显低于对照组[(21.89±2.74)分vs(27.84±3.51)分](P＜0.05)；治疗后，两组血清LPS较治疗前显著降低，HGF较治疗前显著升高(P＜0.05)，观察组血清LPS明显低于对照组，HGF明显比对照组高[(0.43±0.05)ng/mLvs(0.60±0.09)ng/mL，(389.56±27.40)pg/mL vs(301.23±22.30)pg/mL](P＜0.05)。对照组和观察组治疗期间不良反应总发生率分别为8.89%(4/43)、13.95%(6/43)，差异无统计学意义(P＞0.05)。结论：自体干细胞移植治疗失代偿期患者可明显改善肝功能、肝脏储备功能及血清LPS、HGF的表达，且安全性高。 |
| 英文摘要: |
| ABSTRACT Objective: To study curative efficacy of autologous stem cell transplantation in the treatment of decompensated cirrhosis and its effects on the liver reserve function, serum endotoxin(LPS) and hepatocyte growth factor(HGF) levels. Methods: 86 patients of decompensated cirrhosis who received therapy from September 2015 to September 2017 in our hospital were selected as research objects, according to random number table, they were divided into the observation group and the control group, 43 cases in each group. The control group was given conventional comprehensive treatment for decompensated cirrhosis, and the observation group was treated with autologous stem cell transplantation on the basis of the control group. The changes of laboratory indexes, end-stage liver disease model system score (MELD), serum LPS and HGF levels before treatment and 12 weeks after treatment and adverse reactions were compared between the two groups. Results: After treatment, the alanine aminotransferase (ALT), aspartate aminotransferase (AST) and total bilirubin (TBil) levels of two groups were significantly lower than those before treatment, and albumin (ALB) was significantly rise than before treatment(P＜0.05), the ALT, AST and TBil levels in the observation group were significantly lower than those in the control group, and ALB levels was significantly higher than those in the control group[(45.60±4.12)U/L vs. (56.84±6.20)U/L, (57.45±5.01)U/L vs. (68.99±6.84)U/L, (36.53±3.45)g/L vs. (30.42±2.89)g/L, (50.23±4.83)μmol/L vs. (62.30±6.76)μmol/L](P＜0.05); after treatment, the MELD scores of the two groups were significantly lower than those before treatment(P＜0.05), the MELD score in the observation group was significantly lower than those in the control group[(21.89±2.74)scores vs. (27.84±3.51)scores](P＜0.05); after treatment, the serum LPS in the two groups was significantly lower than those before the treatment, and the HGF was significantly higher than that before the treatment(P＜0.05), and the serum LPS in the observation group was significantly lower than those in the control group, and the HGF was significantly higher than those in the control group[(0.43±0.05)ng/mL vs. (0.60±0.09)ng/mL, (389.56±27.40)pg/mL vs. (301.23±22.30)pg/mL](P＜0.05). The incidence of adverse reactions in the control group and the observation group was 8.89% (4/43) and 13.95% (6/43) respectively, and the difference was not statistically significant(P＞0.05). Conclusion: Autologous stem cell transplantation in the treatment of decompensated patients can effectively improve the liver function, liver reserve function and the expression of serum LPS and HGF, and the safety is high. |
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