| 王咏梅,刘世明,周海燕,单 莉,马晓红.加味二妙颗粒联合重组人干扰素a2b阴道泡腾胶囊治疗宫颈上皮内瘤变的疗效及对患者免疫功能的影响[J].,2019,19(24):4736-4739 |
| 加味二妙颗粒联合重组人干扰素a2b阴道泡腾胶囊治疗宫颈上皮内瘤变的疗效及对患者免疫功能的影响 |
| Clinical Efficacy of Jiawei Ermiao Granules Combined with Recombinant Human Interferon A2b Vaginal Effervescent Capsule in the Treatment of Cervical Intraepithelial Neoplasia and Its Effect on the Immune Function |
| 投稿时间：2019-06-05 修订日期：2019-06-27 |
| DOI：10.13241/j.cnki.pmb.2019.24.031 |
| 中文关键词: 宫颈癌 宫颈上皮内瘤变 感染蛋白 二妙颗粒 重组人干扰素a2b阴道泡腾胶囊 |
| 英文关键词: Cervical cancer Cervical intraepithelial neoplasia Infectious protein Ermiao granules Recombinant human interferon a2b vaginal |
| 基金项目:陕西省科技社会发展项目(2017SF007) |
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| 中文摘要: |
| 摘要 目的：探讨加味二妙颗粒联合重组人干扰素a2b阴道泡腾胶囊治疗宫颈上皮内瘤变的疗效及对患者免疫功能的影响。方法：将西北妇女儿童医院妇科门诊自2018年1月至2019年1月收治的确诊为宫颈上皮内瘤变患者300例作为研究对象，将其随机的分为研究组和对照组，每组各150例。研究组患者给予加味二妙颗粒联合重组人干扰素a2b阴道泡腾胶囊进行治疗，对照组患者给予重组人干扰素a2b阴道泡腾胶囊进行治疗，比较两组患者治疗后的临床总有效率，治疗前后CD3+、CD4+、CD8+、NK细胞水平和中医证候评分的变化及不良反应的发生情况。结果：治疗后，研究组临床总有效率为91.33 %，明显高于对照组(74.67 %，P＜0.05)。两组治疗后CD3+、CD4+、CD8+、NK细胞水平均较治疗前明显升高，且研究组以上指标显著高于对照组(P＜0.05)。研究组治疗后中医证候评分降低程度明显优于对照组，其不良反应发生率为10.00 %，明显低于对照组(28.67 %，P＜0.05)。结论：与单用重组人干扰素a2b阴道泡腾胶囊治疗相比，加味二妙颗粒联合使用重组人干扰素a2b阴道泡腾胶囊治疗宫颈上皮内瘤变患者可显著提高患者的免疫功能，缓解症状，提高治疗效果，且安全性更高。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical efficacy of Jiawei Ermiao Granules combined with recombinant human interferon a2b vaginal effervescent capsule in the treatment of cervical intraepithelial neoplasia and its effect on the immune function. Methods: 300 patients with cervical intraepithelial neoplasia who were admitted to the gynecological clinic of Northwest Women's and Children's Hospital from January 2018 to January 2019 were randomly divided into study group and control group, there were 150 patients in each group. The patients in study group were treated with Jiawei Ermiao Granules and recombinant human interferon a2b vaginal effervescent capsules. The patients in control group were treated with recombinant human interferon a2b vaginal effervescent capsules. These indexes were compared in the two groups which include the clinical total effective rate, the changes of CD3+, CD4+, CD8+, NK cell level before and after treatment, the changes of TCM syndrome scores and the occurrence of adverse reactions. Results: After treatment, the total effective rate of the study group was 91.33%, which was significantly higher than that of the control group (74.67%, P<0.05). The levels of CD3+, CD4+, CD8+ and NK cells after treatment were significantly higher than that before treatment, and the study group of the above-mentioned indexes was significantly higher than that of the control group (P<0.05). After treatment, the reduction of syndrome score in the study group was significantly better than that of the control group. The incidence of adverse reactions was 10.00%, which was significantly less than that of the control group (28.67%, P<0.05). Conclusion: Compared to the treatment with recombinant human interferon a2b vaginal effervescent capsule, the treatment with Jiawei Ermiao Granules combined with recombinant human interferon a2b vaginal effervescent capsule can significantly improve the immune function, relieve symptoms, improve the therapeutic effect of patients, and possess higher safety in cervical intraepithelial neoplasia. |
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