| 曾雪华,祁永健,吕晓静,张静莹,谈 欧.阻塞性睡眠呼吸暂停低通气综合征血压变异性及运动心肺功能与病情的相关性分析[J].,2019,19(24):4711-4714 |
| 阻塞性睡眠呼吸暂停低通气综合征血压变异性及运动心肺功能与病情的相关性分析 |
| Blood Pressure Variability in Obstructive Sleep Apnea Hypopnea Syndrome and Correlation between Exercise Cardiopulmonary Function and Condition |
| 投稿时间：2019-04-04 修订日期：2019-04-28 |
| DOI：10.13241/j.cnki.pmb.2019.24.025 |
| 中文关键词: 阻塞性睡眠呼吸暂停低通气综合征 血压变异性 心肺功能 病情 相关性 |
| 英文关键词: Obstructive sleep apnea hypopnea syndrome Blood pressure variability Cardiopulmonary function Condition Correlation |
| 基金项目:江苏省自然科学基金面上项目（BK20151239） |
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| 中文摘要: |
| 摘要 目的：探讨阻塞性睡眠呼吸暂停低通气综合征（OSAHS）血压变异性及运动心肺功能与病情的相关性分析。方法：选取2017年2月~2018年11月期间我院收治的OSAHS患者119例为研究对象，根据每小时睡眠呼吸暂停次数（AHI）将患者分为轻度组（AHI：5~20次/h，n=45）、中度组（AHI：21~40次/h，n=39）、重度组（AHI：>40次/h，n=35），检测所有研究对象的血压变异性及运动心肺功能，并作组间比较。采用Pearson积矩相关分析OSAHS患者血压变异性及运动心肺功能与病情的相关性。结果：OSAHS患者收缩压（SBP）昼、舒张压（DBP）夜以及中度组、重度组SBP夜均高于对照组（P<0.05）；重度组DBP夜以及中度组、重度组SBP昼、SBP夜高于轻度组（P<0.05）；重度组SBP夜、SBP昼、DBP夜高于中度组（P<0.05）；而各组DBP昼整体比较差异无统计学意义（P>0.05）。OSAHS患者最大摄氧量占预计值百分比（VO2 max%pred）、最大摄氧量峰值占预计值百分比（peak VO2%pred）、无氧阈值（AT）、摄氧量功率比值（VO2/WR）、呼吸储备（VEmax/MVV）均低于对照组，且随病情严重程度的增加而降低（P<0.05），OSAHS患者二氧化碳通气当量（VE/VCO2）高于对照组，且随病情严重程度的增加而升高（P<0.05）。Pearson积矩相关分析结果显示，OSAHS患者病情严重程度与SBP昼、SBP夜、DBP夜、VE/VCO2呈正相关（P<0.05），与VO2 max%pred、peakVO2%pred、AT、VEmax/MVV、VO2/WR呈负相关（P<0.05），与DBP昼无相关性（P>0.05）。结论：血压变异性及运动心肺功能指标可反映OSAHS患者病情严重程度，可考虑作为早期监测指标并参考指导治疗。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the blood pressure variability and the correlation between exercise cardiopulmonary function and the condition of obstructive sleep apnea hypopnea syndrome (OSAHS). Methods: 119 patients with OSAHS who were admitted to our hospital from February 2017 to November 2018 were selected as the study subjects. According to the number of sleep apnea per hour (AHI), the patients were divided into mild group (AHI:5-20 times/h, n=45), moderate group (AHI:21-40 times/h, n=39), severe group (AHI:>40 times/h, n=35). The blood pressure variability and exercise cardiopulmonary function of all the subjects were measured. Intergroup comparison was made. Pearson cumulative moment correlation was used to analyze the correlation between blood pressure variability and exercise cardiopulmonary function and the condition in patients with OSAHS. Results: Systolic blood pressure (SBP) day, diastolic blood pressure (DBP) night, moderate and severe SBP night in OSAHS patients were higher than those in control group (P<0.05). SBP day and SBP night in severe group and moderate group were higher than those in mild group(P<0.05). SBP night, SBP day and DBP night in severe group were higher than those in moderate group (P<0.05). There was no significant difference in DBP day between groups (P>0.05). The percentage of VO2 max% pred, peak VO2% pred, anaerobic threshold(AT), VO2/WR and VEmax/MVV of OSAHS patients were lower than those of control group, and they decreased with the increase of the severity of the disease(P<0.05). The VE/VCO2 in OSAHS patients was higher than that in the control group, and it increased with the increase of the severity of the disease (P<0.05). Pearson product moment correlation analysis showed that the severity of OSAHS was positively correlated with SBP day, SBP night, DBP night, VE/VCO2 (P<0.05), negatively correlated with VO2 max% pred, peak VO2% pred, AT, VE max/MVV, VO2/WR(P<0.05), but not correlation with DBP day(P>0.05). Conclusion: Blood pressure variability and exercise cardiopulmonary function can reflect the severity of OSAHS patients, and can be used as early monitoring indicators and guidance for treatment. |
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