| 刘胜楠,刘 洋,吴传安,罗裕旋,高菊逸,梁红艳,刘家仁,姜晓峰.SUMF2对炎症的影响[J].,2019,19(23):4586-4588 |
| SUMF2对炎症的影响 |
| The Effect of SUMF2 on Inflammation |
| 投稿时间：2019-05-08 修订日期：2019-05-31 |
| DOI：10.13241/j.cnki.pmb.2019.23.043 |
| 中文关键词: 硫酸酯酶修饰因子2 硫酸酯酶 炎症 |
| 英文关键词: Sulfate-modifying factor 2 Sulfatase Inflammation |
| 基金项目:国家自然科学基金项目（81171657） |
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| 中文摘要: |
| 摘要：炎症是机体的一种适应性反应，失调时将会对自身机体造成损伤。研究表明许多疾病的发生发展均与炎症的失调有关。硫酸酯酶作为人体不可或缺的蛋白质家族与炎症之间有着密切关联。发热是炎症最主要的表现形式，硫酸酯酶修饰因子2(sulfa- tase-modifying factor 2，SUMF2)参与硫酸酯酶的激活且与发热密切相关。脂多糖刺激人体后，SUMF2的表达明显降低。SUMF2已被证实与白细胞介素-13(Interleukin -13,IL-13)之间存在相互作用，且能在体外水平抑制IL-13的分泌，IL-13可以通过抑制炎性因子的产生发挥抗炎作用。本文将就硫酸酯酶、SUMF2及其对炎症之间的影响进行综述。 |
| 英文摘要: |
| ABSTRACT: Inflammation is an adaptive response to the body, which will cause damage to the body. Research shows that the de- velopment of many diseases is related to the disorder of inflammation. As an indispensable protein family of the human body, the sulfated enzyme has a close association with inflammation. Sulfatase esterase Modifier 2 (SUMF2) is involved in the activation of sulfate esterase and is closely related to fever. Fever is the most important manifestation of inflammation. After the lipopolysaccharide stimulated the hu- man body, the expression of the SUMF2 was significantly reduced. SUMF2 has been confirmed to interact with interleukin -13 (IL-13) and can inhibit IL-13 secretion in vitro. IL-13 can play an anti-inflammatory role by inhibiting the production of inflammatory factors. This article will review the effect of sulfated esterase, SUMF2 and their effect on inflammation. |
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