文章摘要
陈 璐,陈先社,许怀利,王捷虹,赵唯含,田 莉.树突状细胞对胃癌前病变的免疫保护分析[J].,2019,19(22):4396-4400
树突状细胞对胃癌前病变的免疫保护分析
Immunoprotection of Dendritic Cells Against Precancerous Lesions of Gastric Cancer
投稿时间:2019-01-31  修订日期:2019-02-27
DOI:10.13241/j.cnki.pmb.2019.22.043
中文关键词: 树突细胞  癌前病变  免疫保护
英文关键词: Dendritic cells  Precancerous lesions  Immune protection
基金项目:陕西省中医药管理局基金项目(2018JQ8009)
作者单位E-mail
陈 璐 陕西中医药大学附属医院消化一科 陕西 咸阳 712000 chenlu19841123@163.com 
陈先社 安康市中心医院消化科 陕西 安康 725000  
许怀利 西电集团医院消化内科 陕西 西安 710077  
王捷虹 陕西中医药大学附属医院消化一科 陕西 咸阳 712000  
赵唯含 陕西中医药大学附属医院消化一科 陕西 咸阳 712000  
田 莉 西电集团医院消化内科 陕西 西安 710077  
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中文摘要:
      摘要 目的:探究树突状细胞(Dendritic cells,DC)对胃癌的免疫保护作用。方法:选择2016年1月至2018年1月于我院接受治疗的145例胃癌、39例慢性萎缩性胃炎、21例不典型增生、27例肠上皮化生以及20例正常对照组患者为研究对象,分别采集其胃粘膜标本进行染色,记录和比较其胃粘膜中S100+、CD4+和CD8+细胞的数量、平均面积以及平均吸光度,并将胃癌患者分为中分化腺癌(49例)、低分化腺癌(53例)和未分化癌(43例)进行对比。结果:(1)胃癌组、慢性萎缩性胃炎组、不典型增生、肠上皮化生组的胃粘膜S100+阳性细胞计数明显高于正常对照组(P<0.05),胃癌组平均吸光度低于对照组,其他3组平均吸光度显著高于对照组,(P<0.05);胃癌组平均面积与正常对照组相比无差异(P>0.05),其他三组平均面积显著高于对照组(P<0.05);(2)慢性萎缩性胃炎组、肠上皮化生组、不典型增生组患者CD4+细胞数均低于对照组(P<0.05);胃癌组、慢性萎缩性胃炎组、肠上皮化生组患者平均面积均低于对照组(P<0.05);胃癌组、慢性萎缩性胃炎组、不典型增生、肠上皮化生组平均吸光度均低于对照组(P<0.05);(3)慢性萎缩性胃炎组、肠上皮化生组、不典型增生组患者CD8+细胞数明显高于对照组(P<0.05),胃癌组稍低于对照组(P>0.05);胃癌组患者平均面积低于对照组(P<0.05);胃癌组患者平均吸光值低于对照组,慢性萎缩性胃炎组、肠上皮化生组患者高于对照组(P均<0.05);(4)随着胃癌分化程度的降低,胃癌患者DC细胞数有降低趋势。结论:胃癌前病变患者胃粘膜中DC数量会显著增多,免疫功能加强,DC细胞数量会随胃癌分化程度的降低而减少,分析其原因与DC细胞能够抑制癌前病变有关。
英文摘要:
      ABSTRACT Objective: To explore the immunoprotective effect of dendritic cells (DC) on the gastric cancer. Methods: 145 cases of gastric cancer, 39 cases of chronic atrophic gastritis, 21 cases of atypical hyperplasia, 27 cases of intestinal metaplasia and 20 cases of normal control group treated in our hospital from January 2016 to January 2018 were selected as the subjects. Gastric mucosa specimens were stained and observed by image analyzer. The number of S100+, CD4+ and CD8+ cells in the gastric mucosa and the average face area were recorded. The volume and average absorbance were compared, and the patients with gastric cancer were divided into the differentiated adenocarcinoma (49 cases), poorly differentiated adenocarcinoma (53 cases) and undifferentiated carcinoma (43 cases). Results: (1) The gastric mucosal S100+ positive cells in the gastric cancer group, chronic atrophic gastritis group, atypical hyperplasia and intestinal metaplasia group were significantly higher than that in the normal control group (P<0.05). The average absorbance in the gastric cancer group was lower than that in the control group, which were significantly higher in the other 3 groups than that in the control group (P>0.05). (2) The number of CD4+ cells in the chronic atrophic gastritis group, intestinal metaplasia group and atypical hyperplasia group were lower than that in the control group (P<0.05). The average area of patients in the gastric cancer group, chronic atrophic gastritis group and intestinal metaplasia group was lower than that in the control group (P<0.05), the average absorbance of the gastric cancer group, the chronic atrophic gastritis group, the atypical hyperplasia, and the intestinal metaplasia group were lower than that in the control group (P<0.05). (3)The number of CD8+ cells in the chronic atrophic gastritis group, intestinal metaplasia group and atypical hyperplasia group were significantly higher than that in the control group (P<0.05), which was slightly lower in the gastric cancer group than that of the control group (P>0.05); the average area of gastric cancer group was lower than that of the control group (P<0.05); the average absorbance of patients with gastric cancer was lower than that of the control group, and the patients with chronic atrophic gastritis and intestinal metaplasia were higher than the control group (P<0.05). (4) With the decrease of gastric cancer differentiation, the number of DC cells in gastric cancer patients tended to decrease. Conclusion: The number of DC in gastric mucosa of patients with precancerous lesions is significantly increased, and the immune function is strengthened. The number of DC cells is decrease with the decrease of differentiation of gastric cancer, indicating that DC cells may inhibit precancerous lesions.
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