文章摘要
崔 翠,孙彩霞,赵军波,严肖啸,张 洁.2型糖尿病视网膜病变患者血清Chemerin、TNF-α及Cys C水平变化及其临床意义[J].,2019,19(22):4392-4395
2型糖尿病视网膜病变患者血清Chemerin、TNF-α及Cys C水平变化及其临床意义
Changes of Serum Chemerin,TNF-α and Cys C Levels in Patients with Type 2 Diabetic Retinopathy and Their Clinical Significance
投稿时间:2019-03-07  修订日期:2019-03-31
DOI:10.13241/j.cnki.pmb.2019.22.042
中文关键词: 糖尿病视网膜病变  趋化素  肿瘤坏死因子-α  胱抑素C  相关性
英文关键词: Diabetic retinopathy  Chemerin  Tumor necrosis factor-α  Cystatin C  Correlation
基金项目:河北省卫计委青年科技项目(20180517)
作者单位E-mail
崔 翠 河北省邯郸市中心医院眼科 河北 邯郸 056000 537039406@qq.com 
孙彩霞 河北省邯郸市中心医院眼科 河北 邯郸 056000  
赵军波 河北省邯郸市中心医院眼科 河北 邯郸 056000  
严肖啸 河北省邯郸市中心医院眼科 河北 邯郸 056000  
张 洁 河北医科大学附属第二医院美容科 河北 石家庄 050000  
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中文摘要:
      摘要 目的:研究2型糖尿病视网膜病变(DR)患者血清趋化素(Chemerin)、肿瘤坏死因子-α(TNF-α)及胱抑素C(Cys C)的水平变化及临床意义。方法:以114例2型糖尿病(T2DM)患者为研究对象,分为非DR(NDR)组42例、非增生型DR(NPDR)组38例和增生型DR(PDR)组34例。另外选取38例健康体检者作为正常对照(NC)组。记录并比较四组的临床检查及生化指标及血清Chemerin、TNF-α和Cys C水平,并分析患者临床检查、生化指标与Chemerin、TNF-α、Cys C的相关性以及DR的危险因素。结果:NDR组、NPDR组、PDR组的体质量指数(BMI)、收缩压(SBP)、糖化血红蛋白 (HbA1c)、空腹血糖 (FPG)、胰岛素抵抗指数(HONA-IR)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、Chemerin、TNF-α、Cys C水平均高于NC组,且三组SBP、HbA1c、FPG、HONA-IR、血清Chemerin、TNF-α和Cys C水平逐渐递增(P<0.05)。Pearson相关性分析结果显示,血清Chemerin、TNF-α、Cys C与SBP、HbA1c、FPG、HONA-IR、TG、TC、LDL-C均呈正相关关系(P<0.05),且Chemerin、Cys C、TNF-α三者亦呈正相关关系(P<0.05)。多因素Logistic回归分析结果显示,HONA-IR、HbA1c、Chemerin、Cys C和TNF-α均为DR的独立危险因素。结论:高水平Chemerin、TNF-α和Cys C可能与DR的发生、发展有关,三者互相促进,均为DR发生发展的独立危险因素,可用于DR患者的早期诊断及其病情严重程度的判断。
英文摘要:
      ABSTRACT Objective: To study the changes of serum chemerin, tumor necrosis factor-α(TNF-α) and cystatin C (Cys C) levels in patients with diabetic retinopathy (DR) and their clinical significance. Methods: 114 cases of patients with type 2 diabetes mellitus (T2DM) were selected as the subjects. They were divided into non-DR (NDR) group (42 cases), non-proliferative DR (NPDR) group (38 cases) and proliferative DR (PDR) group (34 cases). 38 healthy subjects were selected as normal control (NC group). The clinical examinations, biochemical indexes and serum levels of Chemerin, TNF-alpha and C ys C were recorded and compared in the four groups. The correlation of clinical examination and biochemical indexes with hemerin, TNF-α, Cys C and the risk factors of DR in patients were analyzed. Results: The levels of body mass index (BMI), systolic blood pressure (SBP), Glycosylated hemoglobin (HbA1c), fasting blood glucose (FPG), insulin resistance index (HONA-IR), triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), Chemerin, TNF-α, Cys C in NDR group, NPDR group and PDR group were higher than those in NC group.Moreover, the levels of SBP, HbA1c, FPG, HONA-IR, serum Chemerin, TNF-α and Cys C gradually increased in the three groups (P<0.05). Pearson correlation analysis showed that serum Chemerin,TNF-a, Cys C were positively correlated with SBP, HbA1c, FPG, HONA-IR, TG, TC and LDL-C (P<0.05). Chemerin, Cys C and TNF-α were also positively correlated (P<0.05). Multivariate logistic regression analysis showed that HONA-IR, HbA1c, Chemerin, Cys C and TNF-α were independent risk factors for DR. Conclusion: High levels of Chemerin, TNF-α and Cys C may be related to the occurrence and development of DR. The three are promoting each other. They are independent risk factors for the occurrence and development of DR, it can be used for the early diagnosis of DR patients and the judgment of the severity of the disease.
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