| 王景胜,张 立,刘正君,郭景阳,高会广.慢性阻塞性肺疾病急性加重期患者血清SAA水平与肺功能、炎性因子的相关性及其诊断价值分析[J].,2019,19(22):4330-4334 |
| 慢性阻塞性肺疾病急性加重期患者血清SAA水平与肺功能、炎性因子的相关性及其诊断价值分析 |
| Correlation and Diagnostic Value of Serum Amyloid A Level with Pulmonary Function and Inflammatory Factors in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease |
| 投稿时间：2019-02-27 修订日期：2019-03-23 |
| DOI：10.13241/j.cnki.pmb.2019.22.028 |
| 中文关键词: 慢性阻塞性肺疾病 急性加重期 血清淀粉样蛋白A 肺功能 诊断价值 炎症因子 |
| 英文关键词: Chronic obstructive pulmonary disease Acute exacerbation Serum amyloid A Pulmonary function Diagnostic value Inflammatory factors |
| 基金项目:山东省科学技术发展计划项目（005150203） |
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| 中文摘要: |
| 摘要 目的：探讨慢性阻塞性肺疾病急性加重期（AECOPD）患者血清淀粉样蛋白A（SAA）水平与肺功能及炎性因子的相关性，并分析其诊断价值。方法：选取2013年6月-2018年6月中国人民解放军第970医院收治的204例慢性阻塞性肺疾病（COPD）患者作为研究对象，其中COPD稳定期患者132例作为COPD稳定组，AECOPD患者72例作为AECOPD组。另选取同期于中国人民解放军第970医院进行健康体检的50例健康体检者作为健康组。比较三组受试者血清SAA水平、白细胞介素-8（IL-8）、白细胞介素-6（IL-6）、C反应蛋白（CRP）、降钙素原（PCT）水平及肺功能，采用Pearson相关性分析AECOPD患者血清SAA水平与肺功能及炎性因子的相关性，并分析SAA对AECOPD的诊断价值。结果：AECOPD组患者血清SAA、PCT、CRP、IL-6、IL-8水平较COPD稳定组及健康组升高（P<0.05），COPD稳定组患者血清SAA、IL-6、IL-8、PCT、CRP水平均高于健康组，差异有统计学意义（P<0.05）；AECOPD组患者第一秒用力呼气容积（FEV1）、用力肺活量（FVC）、第一秒用力呼吸容积占用力肺活量的百分比（FEV1/FVC%）、第一秒用力呼气容积占预计值百分比（FEV1%）低于COPD稳定组及健康组，差异有统计学意义（P<0.05），COPD稳定组患者FEV1、FVC、FEV1/FVC%、FEV1%低于健康组，差异有统计学意义（P<0.05）。Pearson相关性分析显示，AECOPD患者血清SAA水平与IL-8、IL-6、CRP、PCT呈正相关，与FEV1%、FEV1/ FVC%、FEV1、FVC呈负相关（P<0.05） 。受试者工作特征（ROC）曲线结果显示，SAA对AECOPD诊断的敏感度为80.85%，特异度为80.07%，曲线下面积为0.832。结论：AECOPD患者血清SAA水平明显升高，其与患者肺功能及炎症因子存在相关性，具有较高的诊断价值，可用于AECOPD患者病情的评估。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the correlation between serum amyloid A (SAA) level and pulmonary function, inflammatory factors in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD), and the diagnostic value was analyzed. Methods: 204 patients with chronic obstructive pulmonary disease (COPD) who were admitted to The 970th Hospital of People's Liberation Army from June 2013 to June 2018 were selected as COPD stable group, 72 patients with AECOPD were selected as AECOPD group. Another 50 healthy persons who underwent physical examination in The 970th Hospital of People's Liberation Army during the same period were selected as the health group. The levels of serum SAA, interleukin-8 (IL-8), interleukin-6 (IL-6), C-reactive protein (CRP), procalcitonin (PCT) and lung function were compared among the three groups. Pearson correlation was used to analyze the correlation between serum SAA level and pulmonary function and inflammatory factors in patients with AECOPD, and the diagnostic value of SAA in AECOPD was analyzed. Results: The serum levels of SAA, PCT, CRP, IL-6 and IL-8 in AECOPD group were higher than those in COPD stable group and healthy group (P<0.05). The serum levels of SAA, IL-6, IL-8, PCT and CRP in COPD stable group were higher than those in healthy group, the difference were statistically significant (P<0.05). The forced expiratory volume in one second (FEV1),forced vital capacity (FVC), the percentage of forced vital capacity occupied by the first second forced expiratory volume (FEV1/FVC), and the percentage of forced expiratory volume occupied by the first second forced expiratory volume (FEV1%) in AECOPD group were lower than those in COPD stable group and healthy group, the difference was statistically significant (P<0.05). The FEV1, FVC, FEV1/FVC% and FEV1% in COPD stable group were lower than those in healthy group, the difference was statistically significant (P<0.05). Pearson correlation analysis showed that serum SAA levels in AECOPD patients were positively correlated with IL-8, IL-6, CRP and PCT. It was negatively correlated with FEV1%, FEV1/FVC%, FEV1 and FVC (P<0.05). The results of receiver operation characteristic (ROC) curve showed that the sensitivity of SAA to AECOPD diagnosis was 80.85%, the specificity was 80.07%, the area under the curve was 0.832. Conclusion: The serum SAA level in AECOPD patients is significantly increased, which is correlated with pulmonary function and inflammatory factors. It has high diagnostic value and could be used to evaluate the condition of patients with AECOPD. |
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