文章摘要
朱疆依,冯 波,梅 琳,孙瑞青,郭长存,孙相钊.结肠腺瘤发生的危险因素及和幽门螺杆菌感染的相关性分析[J].,2019,19(22):4278-4282
结肠腺瘤发生的危险因素及和幽门螺杆菌感染的相关性分析
Risk Factors of Colorectal Adenoma and Its Correlation with Helicobacter Pylori Infection
投稿时间:2019-06-07  修订日期:2019-06-30
DOI:10.13241/j.cnki.pmb.2019.22.016
中文关键词: 结肠腺瘤  危险因素  幽门螺旋杆菌
英文关键词: Colorectal adenoma  Risk factors  Helicobacter pylori
基金项目:陕西省社会发展重点项目( 2018ZDXM-SF-053)
作者单位E-mail
朱疆依 空军军医大学第一附属医院消化病医院 消化内科 陕西 西安 710032 yangmei8152@163.com 
冯 波 空军军医大学第一附属医院心血管医院 心脏外科 陕西 西安 710032  
梅 琳 空军军医大学第一附属医院消化病医院 消化内科 陕西 西安 710032  
孙瑞青 空军军医大学第一附属医院消化病医院 消化内科 陕西 西安 710032  
郭长存 空军军医大学第一附属医院消化病医院 消化内科 陕西 西安 710032  
孙相钊 广东廉江市人民医院 消化内科 广东 廉江 524400  
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中文摘要:
      摘要 目的:分析结肠腺瘤发生的危险因素及和幽门螺杆菌(Hp)感染的相关性。方法:选择我院2018年6月~2018年12月收治的180例结肠腺瘤患者,同时选择我院接受结肠镜检查无异常者152例作为对照组。收集和比较两组患者的一般资料,采用14C尿氮呼气试验检测Hp的感染情况,多因素Logistic回归分析结肠腺瘤发生的危险因素。结果:多因素Logistic逐步回归分析结果显示男性、年龄、体质指数24 kg/m2、腹型肥胖、饮酒、吸烟、喜食红肉、喜食果蔬、高脂血症、糖尿病、粪便隐血阳性、肿瘤家族史及Hp阳性是结肠腺瘤发生的危险因素,喜食果蔬为其发生的保护因素。HP阳性率组腺瘤>1 cm、腺瘤数目多发、左结肠率高于Hp阴性组(P<0.05);Hp阳性组和Hp阴性组肠腺瘤患者腺瘤蒂部分型、腺瘤病理类型比较差异无统计学意义(P>0.05)。结论:结肠腺瘤的发生和多种危险因素有关,其中Hp感染可增加结肠腺瘤发生发展风险,临床应将此类高危人群作为结肠腺瘤的重点筛查对象,以降低结肠癌的潜在发生风险。
英文摘要:
      ABSTRACT Objective: To analyze the risk factors of colorectal adenoma and its correlation with helicobacter pylori (Hp) infection. Methods: 180 patients with colorectal adenoma who were treated from June 2018 to December 2018 and 152 patients who received colonoscopy without abnormality in our hospital were selected as the study group and control group. The general data of the two groups were collected and compared. The Hc infection was detected by 14C urinary nitrogen breath test. The risk factors of colon adenoma were analyzed by multivariate logistic regression. Results: Male, age, body mass index of 24 kg/m2, abdominal obesity, drinking, smoking, like eating red meat, like eating fruits and vegetables, hyperlipidemia, diabetes, fecal occult blood positive, a positive family history of cancer and Hp were influencing factors for colorectal adenoma, like eating fruits and vegetables was the protective factors. The HP positive rate group had >1 cm adenoma, multiple adenomas, and the left colon rate was higher than the HP negative group(P<0.05). There was no statistically significant difference in the pathological types of adenoma pedicle type and adenoma in patients with intestinal adenoma between the Hp positive group and the Hp negative group (P>0.05). Conclusion: Colorectal adenoma is related to a variety of risk factors, Hp infection may increase the risk of developing colorectal adenoma. In order to reduce the potential risk of colon cancer, this high-risk group should be the focus of screening for colorectal adenoma.
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