| 刘兴中,朱高平,郑智琴,白明明,罗宇鹏.尿激酶对急性脑梗死患者血管内皮功能及氧化应激的影响及疗效观察[J].,2019,19(21):4143-4147 |
| 尿激酶对急性脑梗死患者血管内皮功能及氧化应激的影响及疗效观察 |
| Effect of Urokinase on the Vascular Endothelial Function and Oxidative Stress in Patients with Acute Cerebral Infarction |
| 投稿时间：2019-02-23 修订日期：2019-03-18 |
| DOI：10.13241/j.cnki.pmb.2019.21.032 |
| 中文关键词: 尿激酶 急性脑梗死 神经功能 血管内皮功能 氧化应激 |
| 英文关键词: Urokinase Acute cerebral infarct Neurological function Vascular endothelial function Oxidative stress |
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| 中文摘要: |
| 摘要 目的：探讨尿激酶治疗对急性脑梗死(ACI)患者内皮功能及氧化应激的影响并观察其临床疗效。方法：选择2016年7月到2017年7月我院神经内科确诊收治的急性脑梗死患者110例为研究对象，依据治疗方法分为常规组和治疗组，每组各55例。常规组患者接受对症基础治疗，治疗组患者在常规治疗基础上联合尿激酶治疗。比较两组患者治疗前后神经功能、内皮功能、氧化应激指标的变化及治疗后的疗效。结果：治疗后，两组患者美国国立卫生研究院卒中量表( NIH Stroke Scale,NIHSS )、神经组织蛋白(S-100β)、神经元特异性烯醇化酶（Neuro-specific enolase，NSE），内皮素-1（Endothelin-1，ET-1）、丙二醛（Malondialdehyde，MDA）、肿瘤坏死因子α（Tumor necrosis factor α，TNF-α）和可溶性血管细胞粘附分子1（Soluble Vascular cell adhesion molecule 1，sVCAM-）1水平均较治疗前显著降低，一氧化氮（Nitric oxide，NO）、超氧化物歧化酶（Superoxide Dismutase, SOD）和谷胱甘肽过氧化物酶（Glutathione peroxidase，GSH-PX）水平均较治疗前明显升高(均P<0.05)。而治疗组NIHSS评分、S-100β、NSE、ET-1、MDA、TNF-α和sVCAM-1水平均明显低于常规组，NO、SOD和GSH-Px水平均显著高于常规组(均P<0.05)。结论：尿激酶治疗ACI患者可显著提高疗效，其可能的机制是减轻患者氧化应激状态，改善血管内皮功能并促进神经功能的恢复。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical efficacy of urokinase on the patients with acute cerebral infarction and its effect on the endothelial function and oxidative stress. Methods: 110 cases of patients with acute cerebral infarction admitted to our hospital from July 2016 to July 2017 were enrolled as the study object. According to the treatment method, they were divided into the conventional group and the treatment group with 55 cases in each group. Patients in the conventional group was given symptomatic basic treatment, and patients in the treatment group were treated with urokinase on the basis of conventional treatment. The efficacy and the changes of neurological function, endothelial function and oxidative stress before and after treatment were compared between the two groups. Results: After treatment, the NIH Stroke Scale (NIHSS), nerve tissue protein(S-100β), neuro-specific enolase (NSE), endothelin-1 (ET-1), malondialdehyde (MDA), tumor necrosis factor α (TNF-α), and soluble Vascular cell adhesion molecule 1 (sVCAM-)1 levels in the two groups of patients were significantly decreased, and the serum nitric oxide (NO), superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) levels in the two groups were significantly higher than before treatment(all P<0.05). The NNIHSS scores, S-100β, NSE, ET-1, MDA, TNF-α sand VCAM-1 levels in the treatment group were significantly lower than those in the conventional group. The serum NO, SOD and GSH-Px levels in the treatment group were higher than those in the conventional group (all P<0.05). Conclusion: Urokinase treatment can significantly improve the efficacy in the treatment of ACI patients, and the possible mechanism is related to reduce the oxidative stres, improve the vascular endothelial function, and promote the recovery of nerve function. |
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