| 韩 秀,田雨灵,杜 媛,饶金荣,卢 群,马爱群.Cys-C、FT3及Apo-A与冠心病严重程度的相关性[J].,2019,19(21):4092-4097 |
| Cys-C、FT3及Apo-A与冠心病严重程度的相关性 |
| Correlation between Cys-C, FT3, Apo-A and the Severity of Coronary Heart Disease |
| 投稿时间：2019-05-23 修订日期：2019-06-18 |
| DOI：10.13241/j.cnki.pmb.2019.21.021 |
| 中文关键词: 胱抑素C 载脂蛋白A 游离三碘甲状腺原氨酸 冠心病 危险因素 |
| 英文关键词: Cystatin C Apolipoprotein A Free triiodothyrogenic acid Coronary artery disease Risk factor |
| 基金项目:陕西省社会发展科技攻关项目(2015SF024) |
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| 中文摘要: |
| 摘要 目的：探讨胱抑素C(Cys-C)、游离三碘甲状腺原氨酸(FT3)和载脂蛋白A(Apo-A)与冠心病严重程度的相关性。方法：选取2017年10月至2018年3月于西安交通大学第一附属医院心血管内科行冠脉造影的患者353例，根据临床症状及冠脉造影结果将其分为急性心肌梗死组(AMI，n=119)、心绞痛组(AP，n=100)和冠脉造影正常组(NT，n=133)。采用免疫比浊法检测胱抑素(Cys-C)、载脂蛋白A(Apo-A)水平，电化学发光法检测游离三碘甲状腺原氨酸(FT3)水平。通过Logistic回归分析Cys-C、FT3及Apo-A与心绞痛和急性心肌梗死的相关性。ROC曲线分析Cys-C、FT3及Apo-A对心绞痛和急性心肌梗死的诊断价值。结果：AMI组、AP组血清Apo-A水平较NT组显著减低(0.97±0.36、0.92±0.45 vs. 1.05±0.32，P＜0.05)；AMI组的FT3水平显著低于NT组和AP组(0.80±0.45 vs. 1.16±0.30、1.06±0.26，P＜0.001)；AP组Cys-C水平高于NT组及AMI组(1.13±0.38 vs. 0.84±0.22、0.94±0.30，P＜0.001)。多因素Logistic回归分析结果显示Cys-C水平与心绞痛的发生呈正相关(B=4.071)，Apo-A和FT3水平与急性心肌梗死发生呈负相关(B=-2.795，-2.844)。ROC曲线分析结果显示Cys-C对心绞痛的诊断价值最大(曲线下面积=0.794)，FT3对急性心肌梗死的诊断价值最大(曲线下面积=0.156)，其次为Apo-A(曲线下面积=0.299)。结论：Cys-C水平升高与冠心病的发生具有显著相关性，而FT3和Apo-A减低与冠心病严重程度有明显相关性。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the correlation between cystatin C (Cys-c), free triiodothyrogenic acid (FT3), apolipoprotein A (Apo-A) and the severity of coronary heart disease. Methods: A total of 353 patients examined by the coronary angiography in the First Affiliated Hospital of Xi'an Jiaotong University from October 2017 to March 2018 were selected. According to the clinical symptoms and coronary angiography results, they were divided into the acute myocardial infarction group (AMI, n=119), angina pectoris group (AP, n=100) and normal coronary angiography group (NT, n=133). The cystatin (Cys-c) and apolipoprotein A (Apo-A) level by immunoturbidimetry, and free triiodogenic thyroine levels (FT3) were detected by electrochemical luminescence and analyzed by Logistic regression and ROC curves. The correlation between Cys-c, FT3, Apo-A and angina or acute myocardial infarction were analyzed by Logistic regression. The diagnostic value of Cys-c, FT3, Apo-A for the angina and acute myocardial infarction were analyzed by ROC curve. Results: The serum Apo-A levels in AMI group and AP group were significantly lower than those in the NT group (0.97±0.36, 0.92±0.45 vs. 1.05±0.32, P<0.05). The FT3 level in the AMI group was significantly lower than that in the NT group and AP group (0.80±0.45 vs. 1.16±0.30, 1.06±0.26, P<0.001). The level of Cys-C in AP group was higher than that in the NT group and AMI group (1.13±0.38 vs. 0.84±0.22, 0.94±0.30, P<0.001). Multivariate Logistic regression analysis showed that Cys-C has positive correlation with angina(B=4.071), Apo-A and FT3 has negative correlation with AMI(B=-2.795，-2.844). ROC curve analysis showed that Cys-C has the largest diagnostic value to angina (area under curve=0.794), and FT3 has the largest diagnostic value to AMI (area under curve=0.156), then was Apo-A(area under curve=0.299). Conclusion: Increased level of Cys-C was significantly correlated with the occurrence of coronary heart disease, while the decreased levels of FT3 and Apo-A were significanltly correlated with the severity of coronary heart disease. |
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