| 曾夙莉,李华桦,梁峰翎,周 艳,莫炯灵.糖尿病肾病患者微炎症状态与营养状况及免疫功能的相关性分析[J].,2019,19(20):3947-3950 |
| 糖尿病肾病患者微炎症状态与营养状况及免疫功能的相关性分析 |
| Analysis of Correlation between Microinflammation and Nutritional Status and Immune Function in Patients with Diabetic Nephropathy |
| 投稿时间：2019-02-26 修订日期：2019-03-22 |
| DOI：10.13241/j.cnki.pmb.2019.20.033 |
| 中文关键词: 糖尿病肾病 微炎症 营养状况 免疫功能 相关性 |
| 英文关键词: Diabetic nephropathy Microinflammation Nutritional status Immune function Correlation |
| 基金项目:湖南省科技厅科技基金资助项目（20150034） |
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| 中文摘要: |
| 摘要 目的：探讨糖尿病肾病（DN）患者微炎症状态与营养状况及免疫功能的关系。方法：选取2015年6月~2018年6月期间我院收治的DN患者90例作为观察组，依据尿微量白蛋白排泄率（UAER）水平将其分为A组（正常白蛋白尿，UAER＜20 μg/min，n=28）、B组（微量白蛋白尿，UAER20~200 μg/min，n=29）、C组（蛋白尿，UAER＞200 μg/min，n=33），另选取同期来我院行健康体检的志愿者40例作为对照组，检测所有研究对象微炎症、营养状况、免疫功能等相关指标并比较，采用Pearson相关性分析微炎症状态指标与营养状况指标及免疫功能指标的相关性。结果：观察组C反应蛋白（CRP）、白介素-6（IL-6）、免疫球蛋白A（IgA）、免疫球蛋白M（IgM）均高于对照组（P<0.05），观察组白蛋白（Alb）、血红蛋白（Hb）、CD3+、CD4+、CD4+/CD8+、免疫球蛋白G（IgG）均低于对照组（P<0.05）。B组、C组CRP、IL-6、IgA、IgM均高于A组，且C组高于B组（P<0.05），B组、C组Alb、Hb、CD3+、CD4+、CD4+/CD8+均低于A组，且C组低于B组（P<0.05），三组IgG比较差异无统计学意义（P>0.05）。经Pearson相关性分析显示，CRP、IL-6与Alb、Hb、CD3+、CD4+、CD4+/CD8+呈负相关（P<0.05），与IgA、IgM呈正相关（P<0.05），与IgG不相关（P>0.05）。结论：DN患者存在不同程度的微炎症、免疫功能下降以及营养不良状况，通过控制或消除促炎因子，提高机体免疫功能，改善机体营养状况，可能对延缓DN的病情发展具有一定的临床意义。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between microinflammation, nutritional status and immune function in patients with diabetic nephropathy (DN). Methods: 90 DN patients who were admitted to our hospital from June 2015 to June 2018 were selected as observation group. They were divided group A (normal albuminuria, UAER<20 μg/min, n=28), group B (microalbuminuria, UAER 20-200 μg/min, n=29), group C (proteinuria, UAER>200 μg/min, n=33) according to the level of urinary microalbumin excretion rate (UAER). Another 40 volunteers who came to our hospital for health examination during the same period were selected as the control group. The microinflammation, nutritional status and immune function and other related indicators were detected and compared in all subjects. Pearson correlation was used to analyze the correlation between microinflammation and nutritional status and immune function. Results: The levels of C-reactive protein (CRP), interleukin-6 (IL-6), immunoglobulin A (IgA) and immunoglobulin M (IgM) in the observation group were higher than those in the control group (P<0.05). The albumin (Alb), hemoglobin (Hb), CD3+, CD4+, CD4+/CD8+, immunoglobulin G (IgG) in the observation group were lower than those in the control group (P<0.05). The CRP, IL-6, IgA and IgM in group B and group C were higher than those in group A, and those in group C were higher than those in group B (P<0.05). The Alb, Hb, CD3+, CD4+, CD4+/CD8+ in group B and group C were lower than those in group A, and those in group C were lower than those in group B (P<0.05). There was no significant difference in IgG among the three groups (P>0.05). Pearson correlation analysis showed that CRP and IL-6 were negatively correlated with Alb, Hb, CD3+, CD4+, CD4+/CD8+ (P<0.05), they were positively correlated with IgA and IgM (P<0.05), but they were not correlated with IgG (P>0.05). Conclusion: The patients with DN have different degrees of microinflammation, immune function decline and malnutrition. It may have certain clinical significance to delay the development of DN by controlling or eliminating proinflammatory factors, improving immune function and nutritional status. |
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