| 张正宇,凌静娴,李 荣,韩 克,朱湘虹,汤晓秋,周怀君.化疗联合孕激素治疗子宫内膜癌分期手术后患者的临床疗效观察[J].,2019,19(20):3871-3874 |
| 化疗联合孕激素治疗子宫内膜癌分期手术后患者的临床疗效观察 |
| Observation of the Clinical efficacy of Chemotherapy combined with Progesterone in the Treatment of Endometrial Carcinoma after Staging Operation |
| 投稿时间：2019-04-03 修订日期：2019-04-27 |
| DOI：10.13241/j.cnki.pmb.2019.20.016 |
| 中文关键词: 子宫内膜癌 分期手术 孕激素 化疗 临床疗效 |
| 英文关键词: Endometrial cancer staging surgery Progesterone Chemotherapy Clinical efficacy |
| 基金项目:江苏省自然科学基金项目(BK20151096) |
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| 中文摘要: |
| 摘要 目的：探讨化疗联合孕激素治疗子宫内膜癌分期手术后患者的近远期疗效。方法：收集我院2010年1月至2015年12月收治的102例子宫内膜癌患者，根据治疗方法分为对照组(52例，给予分期手术+化疗治疗)与研究组(50例，给予分期手术+化疗+孕激素治疗)，两组均连续治疗12周，比较两组患者临床治疗总有效率、局部复发率、远处转移率、3年生存率、生活质量评分及并发症的发生情况。结果：治疗后，研究组和对照组治疗总有效率分别为82.00%、63.46%，研究组显著高于对照组(P<0.05)；研究组的局部复发率为4.00%，远处转移率为2.00%，3年生存率为90.00%，均明显低于对照组(15.38%、11.54%、73.08%，P<0.05)；研究组的心理功能、躯体功能、社会功能、物质生活评分均高于对照组(P<0.05)；髓抑制、胃肠道反应、白细胞下降、肾损伤、血小板减少发生率明显低于对照组(P<0.05)。结论：分期手术联合化疗、孕激素治疗子宫内膜癌患者有较好的近远期疗效，可有效改善患者预后，提高其生活质量。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the short-term and long-term efficacy of chemotherapy combined with progesterone in patients with endometrial cancer. Methods: 102 patients with endometrial cancer admitted to our hospital from January 2010 to December 2015 were enrolled. According to the treatment method, they were divided into control group (52 cases, staged surgery + chemotherapy) and study group (50 cases, given Staged surgery + chemotherapy + progesterone treatment). Both groups were treated continuously for 12 weeks, comparing the total effective rate, local recurrence rate, distant metastasis rate, 3-year survival rate, quality of life score and complications of the two groups. Results: After treatment, the total effective rate of the study group and the control group were 82.00% and 63.46%, respectively, which was significantly higher in the study group than in the control group (P<0.05). The local recurrence rate in the study group was 4.00%, and the distant metastasis rate was 2.00%. The 3-year survival rate was 90.00%, which was significantly lower than that of the control group (15.38%, 11.54%, 73.08%, P<0.05). The psychological function, physical function, social function and material life score of the study group were higher than those of the control group (P<0.05). The incidence of myeloid inhibition, gastrointestinal reactions, leukopenia, renal injury, and thrombocytopenia was significantly lower than that of the control group (P<0.05). Conclusion: Patients with endometrial cancer treated with chemotherapy and progesterone have better short-term and long-term effects, which can effectively improve the prognosis of patients and improve their quality of life. |
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