| 闫泱锦,高好考,李成祥,杨晓伟,张 园.长期应用氨氯地平对老年高血压患者晨峰现象的影响[J].,2019,19(19):3682-3685 |
| 长期应用氨氯地平对老年高血压患者晨峰现象的影响 |
| Effect of Long-term Application of Amlodipine on the Morning Peak Phenomenon in the Elderly Hypertensive Patients |
| 投稿时间：2019-05-07 修订日期：2019-05-30 |
| DOI：10.13241/j.cnki.pmb.2019.19.019 |
| 中文关键词: 老年患者 晨峰 高血压 氨氯地平 长期 |
| 英文关键词: Elderly patients Morning peak Hypertension Amlodipine Long-term |
| 基金项目:国家自然科学基金项目(81670229) |
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| 中文摘要: |
| 摘要 目的：分析长期应用氨氯地平治疗老年高血压患者的效果及对晨峰现象的影响。方法：选取2017年8月至2018年8月本院收治的老年高血压患者164例，按照患者入院顺序交替均分为两组(n=82)。观察组长期给予氨氯地平治疗，对照组给予非洛地平治疗，两组均连续治疗8周后，比较其降压效果及晨峰血压的变化。结果：治疗后，观察组的白昼平均收缩压(Day systolic blood pressure，dSBP)、白昼平均舒张压( Day diastolic blood pressure，dDBP)、夜间平均收缩压(Night systolic blood pressure，nSBP)、夜间平均舒张压(Night diastolic blood pressuren，DBP)、24 h平均收缩压(24 h systolic blood pressure，24hSBP)、24 h平均舒张压(24 h diastolic blood pressure，24hDBP)均低于对照组及治疗前(P＜0.05)；观察组的晨峰值显著低于对照组及治疗前(P＜0.05)；观察组患者的治疗前两组总胆固醇(Total cholesterol，TC)、甘油三酯(Triglyceride，TG)、低密度脂蛋白(Low density lipoprotein cholesterol，LDL-C)显著低于对照组及治疗前(P＜0.05)，高密度脂蛋白(High density lipoprotein cholesterol，HDL-C)HDL-C显著高于对照组及治疗前(P＜0.05)。结论：对老年高血压患者长期应用氨氯地平不但降压安全、有效，且对控制血压晨峰现象具有积极的影响。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the effect of long-term amlodipine in the treatment on elderly hypertensive patients and its effect on Chenfeng phenomenon. Methods: A total of 164 elderly hypertensive patients admitted to our hospital from August 2017 to August 2018 were enrolled and divided into the two groups according to the order of admission(n=82). The observation group was treated with amlodipine for a long time, and the control group was treated with felodipine. After 8 weeks of continuous treatment, the antihypertensive effect and morning blood pressure of the two groups were compared. Results: After 8 weeks of treatment, the average systolic blood pressure of dSBP, dDBP, nSBP, nDBP, 24hSBP and 24hDBP in the observation group were lower than those in the control group and before treatment(P<0.05). The morning peak of the observation group was significantly lower than that of the control group and before treatment(P<0.05). The differences of TC, TG, LDL-C in the observation group were significantly lower than those in the control group and before treatment(P<0.05), HDL-C was significantly higher than the control group and before treatment(P<0.05). Conclusion: Long-term application of amlodipine is not only safe and effective, but also has a positive effect on the control of blood pressure morning peak phenomenon in the treatment of elderly hypertensive patients. |
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