| 胡 玲,董秀娟,付 杏,谢蔓芳,丁 博.去铁酮联合去铁胺治疗重型地中海贫血患儿的疗效及对血糖代谢和铁代谢的影响[J].,2019,19(18):3581-3584 |
| 去铁酮联合去铁胺治疗重型地中海贫血患儿的疗效及对血糖代谢和铁代谢的影响 |
| The Effects of Desferridone Combined with Desferrimide on Blood Sugar Metabolism and Iron Metabolism in Children with Severe Thalassemia |
| 投稿时间：2019-04-05 修订日期：2019-04-27 |
| DOI：10.13241/j.cnki.pmb.2019.18.040 |
| 中文关键词: 去铁胺 去铁酮 重型地中海贫血 疗效 血糖代谢 铁代谢 |
| 英文关键词: Deferoxamine Deferoxanone Severe thalassemia Efficacy Blood sugar metabolism Iron metabolism |
| 基金项目:海南省卫生计生行业科研项目（16A201296） |
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| 中文摘要: |
| 摘要 目的：探讨去铁酮联合去铁胺治疗重型地中海贫血患儿的疗效及对血糖代谢和铁代谢的影响。方法：选取2015年3月~2017年12月期间海南省妇女儿童医学中心儿科收治的127例重型地中海贫血患儿，根据数表法将患儿随机分为对照组（n=63）和研究组（n=64），其中对照组在基础治疗的基础上给予去铁胺治疗，研究组在对照组的基础上联合去铁酮治疗。比较两组患儿临床疗效、治疗前后的血糖代谢和铁代谢情况，记录两组患儿治疗期间不良反应发生情况。结果：研究组患儿治疗后临床总有效率为73.44%（47/64），高于对照组患儿的55.56%（35/63）（P<0.05）。两组患儿治疗后血糖代谢正常率均升高，且研究组高于对照组（P<0.05）。两组患儿治疗后血清铁蛋白（SF）降低，尿铁排泄量（UIE）升高（P<0.05）；研究组治疗后SF低于对照组，UIE高于对照组（P<0.05）。两组不良反应发生率比较无统计学差异（P>0.05）。结论：去铁酮联合去铁胺治疗重型地中海贫血患儿，安全有效，可改善机体铁代谢，提高血糖代谢正常比例，具有一定的临床应用价值。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of desferriamine combined with desferridone on blood sugar metabolism and iron metabolism in children with severe thalassemia. Methods: 127 children with severe thalassemia who were admitted to pediatrics department of Women and Children's Medical Center of Hainan Province from March 2015 to December 2017 were selected, the children were divided into control group (n=63) and research group (n=64) according to random number table method. The control group was treated with desferriamine on the basis of basic treatment, and the research group was treated with desferridone on the basis of the control group. The clinical efficacy, and the blood sugar metabolism and iron metabolism of two groups before and after treatment were compared, and the adverse reactions of the two groups during treatment were recorded. Results: The total clinical effective rate of the research group was 73.44% (47/64), which was significantly higher than 55.56% (35/63) of the control group (P<0.05). The number of children with normal blood sugar metabolism increased after treatment in both groups, and the research group was higher than that in the control group (P<0.05). After treatment, serum ferritin (SF) decreased and urinary iron excretion (UIE) increased in both groups (P<0.05). SF in the research group was lower than that in the control group, and UIE was higher than that in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Deferridone combined with deferriamine are safe and effective in the treatment of children with severe thalassemia, which can improve iron metabolism and increase the normal proportion of blood sugar metabolism. It has certain clinical application value. |
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