| 崔朝杰,邱 旸,郝莹莹,刘义庆,田文君,张 伟,许 瑞,刘春梅,张 庆,渠 滕.TK1与LDH联合检测对非霍奇金淋巴瘤鉴别诊断及疗效评估的作用[J].,2019,19(18):3486-3489 |
| TK1与LDH联合检测对非霍奇金淋巴瘤鉴别诊断及疗效评估的作用 |
| Effect of the Detection of Serum TK1 and LDH Levels on the Differential Diagnosis and Response Evaluation of Non-hodgkin Lymphoma Patients |
| 投稿时间：2019-03-23 修订日期：2019-04-18 |
| DOI：10.13241/j.cnki.pmb.2019.18.018 |
| 中文关键词: 胸苷激酶1 乳酸脱氢酶 非霍奇金淋巴瘤 |
| 英文关键词: Combined detection of serum TK1 and LDH levels has important reference value for the differential diagnosis and efficacy evaluation of NHL patients |
| 基金项目:山东省自然科学基金项目 (ZR2017PH080) |
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| 中文摘要: |
| 摘要 目的：探讨联合检测血清胸苷激酶1(TK1)与乳酸脱氢酶(LDH)水平在非霍奇金淋巴瘤(NHL)患者鉴别诊断及疗效监测中的临床意义。方法：收集2016年1月至2018年6月我院诊治的111例非霍奇金淋巴瘤的初诊患者血清标本，并选择50例正常人血清标本作为对照，采用免疫印迹增强发光法检测TK1浓度，比色法检测LDH浓度。所有患者随访至少1年，分析和比较惰性NHL与侵袭性NHL及各自四类分期之间血清TK1和LDH水平的差异，化疗后完全缓解、部分缓解与未缓解组LDH水平以及NHL患者中血清TK1和LDH的阳性率。结果：高度侵袭性NHL患者和侵袭性NHL患者血清TKI和LDH水平与惰性NHL患者相比显著增高(P＜0.05)，但惰性NHL患者血清TK1和LDH水平与正常组之间差异无统计学意义(P＞0.05)；Ⅲ、IV期侵袭性NHL患者血清TK1和LDH水平与I、Ⅱ期患者相比显著增高(P＜0.05)。与化疗前相比，四次化疗后，完全缓解组NHL患者血清LDH水平下降21.05%，部分缓解组为16.66%，病情稳定组血清LDH水平升高至11.54%，三组NHL患者血清LDH水平比较差异具有统计学意义(P＜0.008)，两组之间的差异均有统计学意义(P＜0.05)。结论：联合检测血清TK1和LDH水平对于NHL患者的鉴别诊断、疗效评估均具有重要参考价值。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the clinical significance of combined detection of serum thymidine kinase 1(TK1) and lactate dehydrogenase (LDH) levels for the differential diagnosis and efficacy monitoring of patients with non-hodgkin's lymphoma (NHL). Methods: The serum samples of 111 newly diagnosed non-hodgkin's lymphoma patients in our hospital from January 2016 to June 2018 were collected, and the serum samples of 50 normal people were selected as the control group. The concentration of TK1 was detected by western blot enhanced luminescence method, and the LDH concentration was detected by colorimetric method. All patients were followed up for at least 1 year to analyze and compare the differences in the serum TK1 and LDH levels between the inert NHL and the aggressive NHL and their respective four stages, as well as the LDH levels in the complete response group, partial response group and non-response group after chemotherapy, as well as the positive rates of serum TK1 and LDH in NHL patients. Results: The serum TKI and LDH levels in the highly aggressive NHL patients and aggressive NHL patients were significantly higher than those in the inactive NHL patients (P < 0.05), but the serum TK1 and LDH levels in the inactive NHL patients showed no significant difference compared with those in the normal group (P>0.05). The serum TK1 and LDH levels of invasive NHL patients at the stage Ⅲand IV were increased significantly compared with stage NHL patients at the stage I, Ⅱ(P<0.05). Compared with that before chemotherapy, the serum LDH level of NHL patients in the complete response group decreased by 21.05% after four times of chemotherapy, which was 16.66% and 11.54%in the partial response group and the stable condition group. The difference in serum LDH level of NHL patients in the three groups was statistically significant (P<0.008), and the difference between the two groups was statistically significant (P<0.05). Conclusion: Combined detection of serum TK1 and LDH levels has important reference value for the differential diagnosis and efficacy evaluation of NHL patients. |
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