| 宋彦峰,王淑霞,解建业,王秀霞,孟祥鹏.肺炎衣原体感染与老年急性脑梗死患者炎症因子、血脂水平及血流动力学的关系研究[J].,2019,19(17):3351-3355 |
| 肺炎衣原体感染与老年急性脑梗死患者炎症因子、血脂水平及血流动力学的关系研究 |
| Correlation Research between Chlamydia Pneumoniae Infection and Inflammatory Factors, Blood Lipid Levels and Hemodynamics in Elderly Patients with Acute Cerebral Infarction |
| 投稿时间：2019-02-26 修订日期：2019-03-20 |
| DOI：10.13241/j.cnki.pmb.2019.17.032 |
| 中文关键词: 肺炎衣原体 老年 急性脑梗死 炎症因子 血脂 血流动力学 |
| 英文关键词: Chlamydia pneumoniae Elderly Acute cerebral infarction Inflammatory factors Blood lipid Hemodynamics |
| 基金项目:山东省医药卫生科技发展计划项目（2015WS0354） |
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| 中文摘要: |
| 摘要 目的：研究肺炎衣原体（CP）感染与老年急性脑梗死患者炎症因子、血脂水平及血流动力学的关系。方法：选择老年急性脑梗死患者（n=120）和同期入院的健康体检者（n=120）作为研究对象，分别作为观察组和对照组，采用微量免疫荧光试验（MIF）测定两组的CP特异性抗体A（IgA）、特异性抗体G（IgG）、特异性抗体M（IgM），比较两组的CP抗体阳性率。将观察组依据CP的感染与否分为感染者和未感染者，比较两组血液中炎症因子、血脂水平及血流动力学指标的差异，采用logistic回归方法分析特异性抗体阳性与急性脑梗死的相关性。结果：观察组CP抗体IgA和IgG的阳性率均显著高于对照组（P<0.05），而两组IgM的阳性率比较无统计学差异（P>0.05）；观察组中感染者肿瘤坏死因子-α（TNF-α）、超敏C反应蛋白（hs-CRP）和白细胞介素-6（IL-6）水平均高于未感染者（P<0.05）；感染者总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白（LDL）、载脂蛋白B （ApoB）与全血粘度、血细胞比容、血浆粘度和红细胞聚集指数均显著高于未感染者，而高密度脂蛋白（HDL）水平低于未感染者（P<0.05）；多因素logistic回归分析结果显示IgA、IgG抗体阳性均是急性脑梗死的独立危险因素（P<0.05），而未发现IgM抗体与急性脑梗死的发生有关（P>0.05）。结论：CP感染与老年急性脑梗死的发生发展有关，其机制可能与炎症因子的大量释放、血脂代谢紊乱和血流动力学的改变，从而造成动脉粥样硬化斑块和血栓的形成有关。 |
| 英文摘要: |
| ABSTRACT Objective: To research the correlation between Chlamydia pneumoniae infection (CP) and inflammatory factors, blood lipid levels and hemodynamics in elderly patients with acute cerebral infarction. Methods: The elderly patients with acute cerebral infarction (n=120) and the same period health medical examiners (n=120) who were selected as the research objects, and they were respectively as the observation group and the control group, the specific antibody A(IgA), specific antibody G(IgG) and specific antibody M(IgM) of CP in the two groups were measured by Micro immunofluorescence test (MIF), and the positive rates of CP antibody in the two groups were compared. The observation group was divided into infected persons and uninfected persons according to the infection of CP, and the differences of inflammatory factors, blood lipid levels and hemodynamic indexes in the two groups were compared, the correlation between specific antibody positive and acute cerebral infarction was analyzed by logistic regression. Results: The positive rates of CP antibody IgA and IgG in the observation group were significantly higher than those in the control group (P<0.05), and there was no statistical difference in the positive rate of IgM between the two groups (P>0.05). The levels of tumor necrosis factor-α (TNF-α), hypersensitive C reactive protein (hs-CRP) and interleukin-6 (IL-6) in the observation group were higher than those in the uninfected persons (P<0.05). The total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), apolipoprotein B (ApoB) and whole blood viscosity, blood cell specific volume, plasma viscosity and erythrocyte aggregation index were significantly higher than those in the uninfected persons, and the level of high density lipoprotein (HDL) was lower than that in the uninfected persons (P<0.05). The results of multiple factor Logistic regression analysis showed that the positive IgA and IgG antibodies were independent risk factors for acute cerebral infarction (P<0.05), but no association was found between the IgM antibody and the occurrence of acute cerebral infarction (P>0.05). Conclusion: CP infection was related to the occurrence and development of acute cerebral infarction in the elderly patients, the mechanism may be related to the release of inflammatory factors, the disturbance of blood lipid metabolism and the changes of hemodynamics, this leads to the formation of atherosclerotic plaques and thrombosis. |
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