| 姜 蓉,薛荣亮,鲁 信,石 磊,李 玲.盐酸纳布啡联合舒芬太尼用于腹腔镜下肝癌切除术后静脉自控镇痛的临床观察[J].,2019,19(16):3168-3171 |
| 盐酸纳布啡联合舒芬太尼用于腹腔镜下肝癌切除术后静脉自控镇痛的临床观察 |
| Clinical Observation of Nabuprofen Hydrochloride Combined with Sufentanil for Patient-controlled Intravenous Analgesia after Laparoscopic Hepatectomy |
| 投稿时间：2019-02-05 修订日期：2019-02-27 |
| DOI：10.13241/j.cnki.pmb.2019.16.034 |
| 中文关键词: 腹腔镜 肝癌切除术 盐酸纳布啡 舒芬太尼 静脉自控镇痛 |
| 英文关键词: Laparoscopic Hepatectomy Nabuprofen hydrochloride Sufentanil Patient-controlled intravenous analgesia |
| 基金项目:国家临床重点专科建设基金资助项目（2011873） |
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| 中文摘要: |
| 摘要 目的：探讨盐酸纳布啡联合舒芬太尼用于腹腔镜下肝癌切除术后静脉自控镇痛（PCIA）的临床疗效。方法：选取2016年1月至2018年1月安康市中心医院收治的104例行腹腔镜下肝癌切除术患者，按照随机数字表法将患者分为对照组（n=52）和研究组（n=52）。对照组术后给予舒芬太尼PCIA，研究组术后给予盐酸纳布啡联合舒芬太尼PCIA。比较两组术后6h、24h、48h的视觉模拟量表（VAS）评分和数字镇静量表（NSS）评分。检测并比较两组麻醉诱导前、术毕、术后6h、24h及48h血清中P物质（SP）、神经肽Y（NPY）、多巴胺（DA）、C反应蛋白（CRP）、α1-酸性蛋白（AAG）、结合珠蛋白（HP）、白细胞介素-2（IL-2）、白细胞介素-6（IL-6）及白细胞介素-8（IL-8）水平。记录两组术后48h内不良反应发生情况。结果：研究组术后6h、24h、48h的VAS评分均明显低于对照组（P<0.05）；两组各时间点的NSS评分比较差异均无统计学意义（P>0.05）。研究组术后6h、24h、48h的血清SP、NPY、DA、CRP、AAG、HP、IL-6及IL-8水平均明显低于对照组，血清IL-2水平明显高于对照组（P<0.05）。术后48h内，两组不良反应发生率比较差异无统计学意义（P>0.05）。结论：腹腔镜下肝癌切除术后采用盐酸纳布啡联合舒芬太尼PCIA方案，可缓解全身炎症反应，有效镇痛，且安全性较好。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical efficacy of nabuprofen hydrochloride combined with sufentanil for patient-controlled intravenous analgesia (PCIA) after laparoscopic hepatectomy. Methods: 104 patients after laparoscopic hepatectomy who were treated in Ankang Central Hospital from January 2016 to January 2018 were selected, they were randomly divided into the control group (n=52) and the research group (n=52) according to the random number table method. The control group was given sufentanil PCIA after operation, and the research group was given nabuprofen hydrochloride combined with sufentanil PCIA after operation. The visual analogue scale (VAS) score and digital sedation scale (NSS) score were compared between the two groups at 6h, 24h and 48h after operation. The levels of substance P (SP), neuropeptide Y (NPY), dopamine (DA), C-reactive protein (CRP), α1-acid glycoprotein (AAG), haptoglobin(HP), interleukin-2 (IL-2), interleukin-6 (IL-6) and interleukin-8 (IL-8) between the two groups before anesthesia induction, after operation, 6h, 24h and 48h after operation were detected and compared. The adverse reactions within 48h after operation were recorded between the two groups. Results: The VAS scores of the research group at 6h, 24h and 48h after operation were significantly lower than that in the control group (P<0.05). There were no significantly differences of the NSS scores of the two groups at each time points (P>0.05). The serum levels of SP, NPY, DA, CRP, AAG, HP, IL-6, IL-8 of the research group at 6h, 24h and 48h after operation were significantly lower than those in the control group, the serum level of IL-2 was significantly higher than that in the control group (P<0.05). There was no significantly difference of the adverse reaction rate of the two groups at 48h within after operation (P>0.05). Conclusion: After laparoscopic hepatectomy, nabuprofen hydrochloride combined with sufentanil PCIA, it can relieve systemic inflammatory response, it can effectively relieve pain, and it has good security. |
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