| 巩 博,王 刚,任贻强,黄 鹤,李延光.生大黄保留灌肠对重症急性胰腺炎患者胃肠激素和炎症反应的影响[J].,2019,19(16):3137-3140 |
| 生大黄保留灌肠对重症急性胰腺炎患者胃肠激素和炎症反应的影响 |
| Effect of Rhubarb Retention Enema on Gastrointestinal Hormone and Inflammatory Response in Patients with Severe Acute Pancreatitis |
| 投稿时间：2019-02-04 修订日期：2019-02-28 |
| DOI：10.13241/j.cnki.pmb.2019.16.027 |
| 中文关键词: 生大黄 灌肠 重症急性胰腺炎 胃肠激素 炎症反应 疗效 |
| 英文关键词: Rhubarb Retention enema Severe acute pancreatitis Gastrointestinal hormones Inflammatory response |
| 基金项目:湖北省卫生计生委西医类基金项目（WJ2016Z0249） |
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| 中文摘要: |
| 摘要 目的：探讨生大黄保留灌肠对重症急性胰腺炎（SAP）患者胃肠激素和炎症反应的影响。方法：选取2012年 1月~2017年1月间我院收治的SAP患者110例，采用随机数字表法将患者分为对照组（n=55）和研究组（n=55），对照组给予常规西医治疗，研究组在对照组基础上给予生大黄保留灌肠治疗，比较两组临床疗效、临床指标改善情况、炎症因子、血淀粉酶以及胃肠激素水平。结果：研究组治疗后的临床总有效率为74.55%（41/55），高于对照组患者的54.55%（30/55）（P<0.05）。研究组肠道功能恢复时间、全身炎症反应综合征（SIRS）消退时间、住院天数均短于对照组，研究组并发症发生率低于对照组（P<0.05）。两组患者治疗后白介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、超敏C反应蛋白（hs-CRP）、血淀粉酶水平均降低，且研究组低于对照组（P<0.05）。两组患者治疗后胃动素（MTL）、胆囊收缩素（CCK）水平升高，血管活性肠肽（VIP）水平降低（P<0.05），研究组治疗后MTL、CCK水平高于对照组，VIP水平低于对照组（P<0.05）。结论：生大黄保留灌肠治疗SAP患者疗效确切，可减轻炎症反应，改善患者血淀粉酶水平及胃肠道功能，促进患者恢复。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of rhubarb retention enema on gastrointestinal hormones and inflammatory response in patients with severe acute pancreatitis (SAP). Methods: 110 patients with SAP who were admitted to our hospital from January 2012 to January 2017 were selected, they were randomly divided into control group (n=55) and study group (n=55) by digital table method. The control group was treated with routine western medicine, while the study group was treated with rhubarb retention enema on the basis of the control group. The clinical efficacy, improvement of clinical indicators, inflammatory factors, blood amylase and astrointestinal hormones were compared between the two groups. Results: The total effective rate of the study group after treatment was 74.55% (41/55), which was higher than 54.55% (30/55) of the control group (P<0.05). The recovery time of intestinal function, systemic inflammatory response syndrome (SIRS) subsidence time and hospitalization days in the study group were shorter than those in the control group, and the incidence of complications in the study group was lower than that in the control group (P<0.05). Interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), high-sensitivity C-reactive protein (hs-CRP) and serum amylase in the two groups after treatment were all decreased, and those in the study group were lower than those in the control group (P<0.05). The levels of motilin (MTL) and cholecystokinin (CCK) increased, and vasoactive intestinal peptide (VIP) decreased in both groups after treatment (P<0.05). The levels of MTL and CCK in the study group were higher than those in the control group after treatment, and VIP was lower than that in the control group (P<0.05). Conclusion: Rhubarb retention enema is effective in treating SAP patients. It can alleviate inflammation, improve blood amylase level and gastrointestinal function, and promote recovery of patients. |
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