| 苗 芸,傅玉娟,宋芳霞,贺 莉,蔡东阁,李 刚.雌激素替代疗法对内分泌失调女性内分泌轴功能的影响[J].,2019,19(15):2941-2944 |
| 雌激素替代疗法对内分泌失调女性内分泌轴功能的影响 |
| Effects of Estrogen Replacement Therapy on the Endocrine Axis Function of Endocrine Disorder Women |
| 投稿时间：2018-12-08 修订日期：2018-12-31 |
| DOI：10.13241/j.cnki.pmb.2019.15.032 |
| 中文关键词: 雌激素替代疗法 内分泌失调 内分泌轴功能 女性 血脂 |
| 英文关键词: Estrogen replacement therapy Endocrine disorders Endocrine axis function Female Blood lipid |
| 基金项目:陕西省自然科学基金项目(2014J0326) |
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| 中文摘要: |
| 摘要 目的：探讨雌激素替代疗法对内分泌失调女性内分泌轴功能的影响。方法：选取2014年9月至2018年2月到本院就诊的186例内分泌失调女性患者当作研究对象，根据治疗方法的不同将其分为观察组(给予雌激素替代疗法)100例与对照组(给予常规药物)86例，两组均治疗3个月，比较两组治疗前TC、TG、LDL-C、HDL-C水平、黄体生成素(LH)和雌二醇(E2)水平的变化、疗效与不良反应的发生情况。结果：观察组与对照组治疗后的总有效率分别为98.0%和88.4%，观察组明显高于对照组(P<0.05)。观察组治疗后的血清HDL-C、E2值较对照组显著增加，血清TC、TG与LDL-C、FSH水平均较对照组明显降低(P<0.05)。观察组与对照组治疗期间的主要不良反应为乳房胀痛、乳房包块、肝功能异常、下肢水肿等，组间对比差异无统计学意义(P>0.05)，所有不良反应经过对症处理后好转。结论：雌激素替代疗法治疗内分泌失调女性能调节内分泌轴功能，提高治疗效果，改善临床症状，促使血脂分泌平衡，且安全性好。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of estrogen replacement therapy on the endocrine axis function of women with endocrine disorders. Methods: 186 cases of female patients with endocrine disorders from September 2014 to February 2018 were selected as research subjects. According to the different treatment methods, they were divided into the observation group (100 cases, estrogen replacement therapy) and the control group (86 cases, conventional drugs). Both groups were treated for 3 months. The changes of TC, TG, LDL-C and HDL-C levels, luteinizing hormone (LH) and estradiol (E2) levels, curative effect and incidence of adverse reactions were compared between the two groups before and after treatment. Results: The total effective rates of observation group and control group after treatment were 98.0% and 88.4% respectively, which was significantly higher in the observation group than that of the control group (P<0.05). The serum HDL-C and E2 values of observation group were significantly higher than those of the control group after treatment. The levels of serum TC, TG and LDL-C and FSH were significantly lower than those in the control group (P<0.05). Breast pain, breast mass, abnormal liver function and edema of lower extremities were found in both groups during the treatment. No significant difference between the groups (P>0.05). All the adverse reactions were improved after treatment. Conclusion: Estrogen replacement therapy can regulate the function of the endocrine axis, improve the treatment effect and promote the balance of blood lipid secretion in the treatment of endocrine disorder women with high safety. |
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