| 闫 真,涂金晶,白伶俐,芦 笛,张 娟.甲基多巴联合酚妥拉明治疗妊娠期高血压的临床疗效及安全性研究[J].,2019,19(15):2920-2924 |
| 甲基多巴联合酚妥拉明治疗妊娠期高血压的临床疗效及安全性研究 |
| Efficacy and Safety of Alpha-methyl-dopa Combined with Phentolamine in the Treatment of Gestational Hypertension |
| 投稿时间：2018-12-07 修订日期：2018-12-30 |
| DOI：10.13241/j.cnki.pmb.2019.15.027 |
| 中文关键词: 甲基多巴 酚妥拉明 妊娠期高血压疾病 疗效 安全性 |
| 英文关键词: Alpha-methyl-dopa Phentolamine Hypertensive disorder complicating pregnancy Efficacy Safety |
| 基金项目:陕西省教育厅专项科学研究计划项目(16JK1867) |
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| 中文摘要: |
| 摘要 目的：研究甲基多巴联合酚妥拉明治疗妊娠期高血压的临床疗效及安全性。方法：选择2015年1月～2017年12月我院收治的妊娠期高血压疾病患者210例，并将其随机分为两组。对照组静脉滴注酚妥拉明治疗，每次20 mg，每天1次；观察组联合口服甲基多巴，每次250 mg，每天3次。比较两组的治疗有效率，妊娠情况及治疗前后的收缩压(SBP)、平均动脉压、舒张压(DBP)和尿素氮(BUN)、血肌酐(Cr)、β2 微球蛋白(β2-MG)和尿微量清蛋白(MA)水平的变化。结果：治疗后，观察组的有效率明显高于对照组(P<0.05)；观察组的产后出血、胎盘剥落、子痫前期、羊水栓塞先兆以及剖宫产发生率均明显低于对照组(P<0.05)。两组治疗后的SBP、MAP和DBP均较治疗前明显降低(P<0.05)，且观察组SBP、MAP和DBP明显低于对照组(P<0.05)。两组治疗前后的Cr、BUN水平相比均无明显的差异(P>0.05)，两组治疗后的血清β2-MG和MA水平均较治疗前明显降低(P<0.05)，且观察组以上指标明显低于对照组(P<0.05)。两组的不良反应发生情况相比差异无统计学意义(P>0.05)。结论：甲基多巴联合酚妥拉明治疗妊娠期高血压的临床效果明显优于单用酚妥拉明治疗，其可以更有效控制血压，改善患者肾功能，且安全性较高。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical effect and safety of alpha-methyl-dopa combined with phentolamine in the treatment of gestational hypertension. Methods: 210 cases of patients with gestational hypertension who were treated in our hospital from January 2015 to December 2017 were selected and randomly divided into two groups. The control group was treated with intravenous drip of phentolamine, 20 mg each time, once a day; the observation group was treated with methyldopa, 250 mg each time, three times a day. The efficacy, pregnancy outcome, changes of blood pressure, urea nitrogen (BUN), serum creatinine (Cr), beta 2 microglobulin (beta 2-MG) and urine microalbumin (MA) before and after treatment were compared between two groups. Results: After treatment, the effective rate of observation group was significantly higher than that of the control group(P<0.05); the incidence of postpartum hemorrhage, placental exfoliation, preeclampsia, amniotic fluid embolism and cesarean section in the observation group were significantly lower than those in the control group(P<0.05); the SBP, MAP and DBP of both groups after treatment were significantly lower than those before treatment(P<0.05), which were obviously lower in the observation group(P<0.05); the levels of serum beta 2-MG and MA in both groups were significantly decreased(P<0.05), which were obviously lower in the observation group(P<0.05); there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion: The combination of alpha-methyl-dopa and phentolamine is more effective on patients with gestational hypertension than phentolamine alone. It can more effectively control the blood pressure, improve the renal function with high safety. |
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