| 文 慧,彭彦才,艾葆春,李剑平,郝光军.容积弧形调强放疗同步化疗治疗晚期非小细胞肺癌患者的短期疗效及对血清TSGF、TK1、CA125水平的影响[J].,2019,19(14):2760-2763 |
| 容积弧形调强放疗同步化疗治疗晚期非小细胞肺癌患者的短期疗效及对血清TSGF、TK1、CA125水平的影响 |
| Short-term Clinical Efficacy of Volume-arc Intensity Modulated Radiotherapy in the Treatment of Advanced Non-small Cell Lung Cancer and its Effects on the Serum TSGF, TK1 and CA125 Levels |
| 投稿时间：2019-01-21 修订日期：2019-02-17 |
| DOI：10.13241/j.cnki.pmb.2019.14.034 |
| 中文关键词: 晚期非小细胞肺癌 容积弧形调强放疗 三维适行放疗 肿瘤特异性生长因子 胸苷激酶1 糖类抗原125 |
| 英文关键词: Advanced non-small cell lung cancer Volume-arc intensity modulated radiotherapy Three-dimensional conformal radiotherapy Tumor-specific growth factor Thymidine kinase 1 Carbohydrate antigen 125 |
| 基金项目:陕西省科学技术厅重点研发计划项目(2017SF-207) |
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| 中文摘要: |
| 摘要 目的：探讨容积弧形调强放疗同步化疗治疗晚期非小细胞肺癌患者的短期疗效及对血清肿瘤特异性生长因子(TSGF)、胸苷激酶1(TK1)、糖类抗原125(CA125)水平的影响。方法：选择2015年1月至2018年1月我院接诊的95例晚期非小细胞肺癌患者，按照随机数表法分为观察组48例和对照组47例。观察组使用容积弧形调强放疗，对照组使用三维适行放疗，临床靶区(CTV)剂量均为2.0Gy/次，总剂量50Gy，1次/d，5次/周，两组均使用长春瑞滨+顺铂同步化疗。比较两组的临床疗效、治疗前后血清TSGF、TK1、CA125水平的变化及不良反应的发生情况。结果：治疗后，观察组疾病总缓解率为43.75%，明显高于对照组(23.4%，P＜0.05)，血清TSGF、TK1、CA125均明显低于对照组(P＜0.05)。两组治疗期间胃肠道反应、血液毒性、心脏毒性、骨髓抑制、肝功能损伤、放射性肺炎、放射性食管炎不良反应发生率比较差异均无统计学意义(P＞0.05)。结论：容积弧形调强放疗同步化疗治疗晚期非小细胞肺癌患者的短期效果显著优于三维适行放疗，其可更有效降低血清TSGF、TK1、CA125的表达水平，且安全性更高。 |
| 英文摘要: |
| ABSTRACT Objective: To study the short-term clinical efficacy of Volume-arc intensity modulated radiotherapy in the treatment of advanced non-small cell lung cancer and its effects on the serum umor-specific growth factor(TSGF), Thymidine kinase 1(TK1) and Carbohydrate antigen 125(CA125) levels. Methods: 95 patients of advanced non-small cell lung cancer who were treated from January 2015 to January 2018 in our hospital were selected as the research objects, they were divided into the 48 cases in the observation group and 47 cases in the control group by the random number table. The observation group was treated with volume-arc intensity modulated radiotherapy, while the control group was treated with three-dimensional conformal radiotherapy, the clinical target area (CTV) dose was 2.0Gy/ times, total dose 50Gy, 1/d, 5 times/week, they were treated with chemotherapy combined with rubinbin plus cisplatin in Changchun. The clinical efficacy, changes of the serum TSGF, TK1, CA125 levels before and after treatment and incidence of adverse reactions were compared between the two groups. Results: After treatment, the total remission rate of observation group was 43.75%, which was significantly higher than that in the control group(23.4%, P＜0.05); the serum TSGF, TK1, CA125 levels were significantly lower than those in the control group(P＜0.05); there was no significant difference in the incidence of adverse reactions includingastrointestinal reaction, blood toxicity, cardiotoxicity, myelosuppression, liver function injury, radiation pneumonia and radiation esophagitis between the two groups during treatment(P＞0.05). Conclusion: The short-term effect of volume-arc intensity modulated radiotherapy combined with chemotherapy for advanced non-small cell lung cancer is significantly better than that of three-dimensional suitable radiotherapy, which can effectively reduce the expression of serum TSGF, TK1 and CA125 levels with higher security. |
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