| 张 静,阎晓悦,刘 永,赵 晔,张海文.血府逐瘀汤联合四联疗法治疗Hp阳性慢性萎缩性胃炎的临床观察[J].,2019,19(14):2751-2754 |
| 血府逐瘀汤联合四联疗法治疗Hp阳性慢性萎缩性胃炎的临床观察 |
| Effect of Xuefu Zhuyu Decoction Combined with Quadruple Therapy on the Hp Positive Chronic Atrophic Gastritis |
| 投稿时间：2018-11-06 修订日期：2018-11-30 |
| DOI：10.13241/j.cnki.pmb.2019.14.032 |
| 中文关键词: 血府逐瘀汤 四联疗法 Hp阳性慢性萎缩性胃炎 胃黏膜病理积分 |
| 英文关键词: Xuefu Zhuyu Decoction Quadruple therapy Hp positive chronic atrophic gastritis Gastric mucosal pathological score |
| 基金项目:北京中医药科技发展基金项目(JJ2015-16) |
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| 中文摘要: |
| 摘要 目的：探究血府逐瘀汤联合四联疗法治疗幽门螺旋杆菌(Hp)阳性慢性萎缩性胃炎的效果。方法：回顾性分析2014年5月-2017年12月在我院进行诊治的80例Hp阳性慢性萎缩性胃炎患者的临床资料，按照其入院顺序经随机数字表分为研究组和对照组，每组各40例患者。其中，对照组患者采用四联疗法，研究组患者在对照组基础上联合血府逐瘀汤进行治疗，对比两组患者的Hp转阴率、治疗前后胃黏膜病理积分的变化情况、临床症状积分的变化情况和不良反应发生率。结果：治疗后，研究组患者的Hp转阴率[85.0%(34/40)]显著高于对照组[62.5%(25/40)](P＜0.05)。两组上腹痛、纳差、上腹胀、反酸、嗳气等临床症状积分以及胃黏膜萎缩、肠化、不典型增生等病理积分均显著低于治疗前(P＜0.05)，且研究组以上指标均明显低于对照组(P＜0.05)。研究组患者的不良反应发生率[5.0%(2/40)]与对照组[12.5%(5/40)]无显著性差异(P＞0.05)。结论：血府逐瘀汤联合四联疗法治疗Hp阳性慢性萎缩性胃炎的效果显著优于单用四联疗法，其可有效改善患者的病变程度和临床症状，且无明显不良反应产生。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the effect of Xuefu Zhuyu Decoction combined with quadruple therapy on the Helicobacter pylori (Hp)-positive chronic atrophic gastritis. Methods: 80 cases of patients with Hp-positive chronic atrophic gastritis who were treated in our hospital from May 2014 to December 2017 were selected and randomly divided into the study group and the control group according to the order of admission with 40 patients in each group. Patients in the control group were treated with quadruple therapy, and patients in the study group were treated with Xuefu Zhuyu Decoction on the basis of control group. The Hp negative rate, the changes of gastric mucosal pathological scores and clinical symptom scores before and after treatment as well as the incidence of adverse reactions were compared between two groups. Results: After treatment, the Hp negative rate of study group [85.0%(34/40)] was significantly higher than that of the control group [62.5%(25/40)](P<0.05). The scores of clinical symptoms such as abdominal pain, anorexia, upper abdominal distension, acid reflux and eructation, as well as gastric mucosal atrophy, intestinal metaplasia and atypical hyperplasia were significantly lower than those before treatment(P<0.05). The above indicators of study group were significantly lower than those of the control group (P<0.05). The incidence of adverse reactions in the study group[5.0%(2/40)] was not significantly different from that in the control group[12.5% (5/40)](P＞0.05). Conclusion: Xuefu Zhuyu Decoction combined with quadruple therapy is significantly better than quadruple therapy alone on Hp-positive chronic atrophic gastritis, which can effectively improve the degree of disease and clinical symptoms of patients and there was no obvious adverse reaction. |
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