| 徐 瑶,邓晓杨,吴海燕,周 琴,邓 洁.人乳头状瘤病毒感染与宫颈癌患者临床病理特征和Ki-67、PCNA的关系[J].,2019,19(14):2743-2746 |
| 人乳头状瘤病毒感染与宫颈癌患者临床病理特征和Ki-67、PCNA的关系 |
| Relationship between Human Papillomavirus Infection and Clinicopathological Features, Ki-67, PCNA in Patients with Cervical Cancer |
| 投稿时间：2018-12-08 修订日期：2018-12-30 |
| DOI：10.13241/j.cnki.pmb.2019.14.030 |
| 中文关键词: 宫颈癌 人乳头状瘤病毒 临床病理特征 Ki-67 细胞增殖抗原 |
| 英文关键词: Cervical cancer Human papillomavirus Clinicopathological features Ki-67 Cell proliferation antigen |
| 基金项目:四川省教育厅科研项目（17ZA0128） |
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| 中文摘要: |
| 摘要 目的：研究人乳头状瘤病毒（HPV）感染与宫颈癌患者临床病理特征和Ki-67、细胞增殖抗原（PCNA）的相关性，从而为临床宫颈癌的诊治提供参考依据。方法：选取2016年3月～2018年6月于我院接受手术治疗的宫颈病变患者130例为研究对象。其中宫颈癌患者30例记为宫颈癌组，宫颈上皮内瘤变患者68例记为宫颈上皮内瘤变组，慢性宫颈炎患者32例记为对照组。采用免疫组织化学法检测各组宫颈组织中HPV感染、Ki-67以及PCNA阳性表达情况，并分析HPV与宫颈癌患者临床病理特征的关系及其与Ki-67、PCNA的相关性。结果：宫颈癌组、宫颈上皮内瘤变组患者HPV、Ki-67以及PCNA阳性率均高于对照组，宫颈癌组高于宫颈上皮内瘤变组（均P＜0.05）。临床分期Ⅲ～Ⅳ期以及淋巴结转移宫颈癌患者HPV感染率均明显高于临床分期Ⅰ～Ⅱ期与无淋巴结转移患者（均P＜0.05）。经Spearman相关性分析可得：宫颈癌患者HPV感染与Ki-67、PCNA表达均呈正相关关系（均P＜0.05）。结论：宫颈癌患者存在明显的HPV感染，且HPV感染与宫颈癌患者临床分期、淋巴结转移、Ki-67、PCNA表达存在一定相关性，临床可通过对HPV、Ki-67、PCNA进行联合检测，从而有助于宫颈癌的早期诊断。 |
| 英文摘要: |
| ABSTRACT Objective: To study the correlation between human papillomavirus (HPV) infection and clinicopathological features and Ki-67 and Cell proliferation antigen (PCNA) in cervical cancer patients, so as to provide reference for clinical diagnosis and treatment of cervical cancer. Methods: A total of 130 patients with cervical lesions, who underwent surgical treatment in First Affiliated Hospital of Chengdu Medical College, from March 2016 to June 2018, were chosen as research subjects and divided into three groups: 30 cases of cervical cancer were recorded as cervical cancer group, 68 cases of cervical intraepithelial neoplasia were identified as cervical intraepithelial neoplasia group, and 32 cases of chronic cervicitis as control group. HPV infection, Ki-67 and PCNA positive expression in cervical tissues of each group were examined by immunohistochemistry. The relationship between HPV and clinicopathological characteristics of cervical cancer and its correlation with Ki-67 and PCNA were also analyzed. Results: The positive rates of HPV, Ki-67 and PCNA in the cervical cancer group and the cervical intraepithelial neoplasia group were higher than those in the control group, the above indexes in the cervical cancer group were higher than those in the cervical intraepithelial neoplasia group (all P<0.05). The incidence of HPV infection in patients with stage III to IV and lymph node metastasis of cervical cancer were significantly higher than those in stage I to II and no lymph node metastasis (all P<0.05). Spearman correlation analysis showed that there was a positive correlation between HPV infection and the expression of Ki-67 and PCNA in cervical cancer patients (P<0.05). Conclusion: There is a significant HPV infection in patients with cervical cancer, and there is a certain correlation between HPV infection and the clinical stage, lymph node metastasis, Ki-67 and PCNA expression in the patients with cervical cancer.The combined detection of HPV, Ki-67 and PCNA can help the early diagnosis of cervical cancer. |
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