| 刘雁林,陈海燕,王沛靓,伊 婷,杨 静.宫腔镜子宫内膜电切术治疗功能失调性子宫出血的疗效及对患者性激素水平的影响[J].,2019,19(13):2567-2570 |
| 宫腔镜子宫内膜电切术治疗功能失调性子宫出血的疗效及对患者性激素水平的影响 |
| The effects of Hysteroscopic Endometrial Resection on the Treatment of Dysfunctional Uterine Bleeding and the Sex hormone Levels in Patients |
| 投稿时间：2018-11-24 修订日期：2018-12-18 |
| DOI：10.13241/j.cnki.pmb.2019.13.038 |
| 中文关键词: 宫腔镜 子宫内膜电切术 功能失调性子宫出血 疗效 性激素 |
| 英文关键词: Hysteroscopy Endometrial resection Dysfunctional uterine bleeding Curative effect Sex hormone |
| 基金项目:新疆维吾尔自治区自然科学基金项目（2014C2347） |
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| 中文摘要: |
| 摘要 目的：探讨宫腔镜子宫内膜电切术治疗功能失调性子宫出血的疗效及对患者性激素水平的影响。方法：从本院2016年7月-2017年7月收治的围绝经期功能失调性子宫出血患者中选取94例，按随机数字表法分为对照组和观察组，各47例。对照组采用曼月乐进行治疗，观察组采用宫腔镜子宫内膜电切术治疗。比较两组治疗后3个月、6个月、12个月的治疗效果，检测两组治疗前、治疗后3个月、6个月、12个月血红蛋白（Hb）含量及血清垂体催乳素（PRL）、孕酮（P）、促卵泡生成素（FSH）、促黄体生成素（LH）、睾酮（T）、雌二醇（E2）水平。随访1年，观察两组患者的不良反应发生情况。结果：观察组治疗后3个月、6个月、12个月的总有效率分别为100.00%、95.74%、95.74%，均分别高于对照组的93.62%、89.36%、87.23%，但两组各时期比较差异无统计学意义（P>0.05）。两组患者治疗后3个月、6个月、12个月的Hb含量均高于治疗前，且观察组治疗后3个月、6个月、12个月的Hb含量均明显高于对照组（P<0.05）。 治疗后6个月、12个月，对照组的PRL、P、FSH、LH、T水平均高于治疗前和观察组，而E2水平低于治疗前和观察组（P<0.05）。观察组治疗后3个月、6个月、12个月的各项性激素指标水平与治疗前比较差异均无统计学意义（P>0.05）。观察组不良反应发生率为4.26%，低于对照组的21.28%（P<0.05）。结论：宫腔镜子宫内膜电切术治疗功能失调性子宫出血疗效确切，能明显改善患者贫血状况，且对性激素水平无明显影响，具有较好的安全性。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of hysteroscopic endometrial resection on the treatment of dysfunctional uterine bleeding and its influence on sex hormone levels. Methods: 94 patients with dysfunctional uterine bleeding in perimenopausal period who were admitted to our hospital from July 2016 to July 2017 were selected, they were divided into control group and observation group according to random number table method, they were 47 cases in each group. The control group was treated with intrauterine device, and the observation group was treated with hysteroscopic endometrial resection. The therapeutic effects of the two groups were compared at 3,6 and 12 months after treatment. The hemoglobin (Hb), serum prolactin (PRL), progesterone (P), follicle stimulating hormone (FSH),luteinizing hormone (LH), testosterone (T) and estradiol (E2) levels were compared between the two groups at 3, 6 and 12 months after treatment. Follow up for 1 year, the incidence of adverse reactions were observed in the two groups. Results: The total effective rates of the observation group were 100.00%, 95.74% and 95.74% respectively at 3, 6 and 12 months after treatment, which were higher than those of the control group (93.62%, 89.36% and 87.23% respectively), but there were no significant differences between the two groups at all stages(P>0.05). The levels of Hb in the two groups were higher than those before treatment at 3, 6 and 12 months after treatment, and the levels of Hb in the observation group at 3, 6 and 12 months after treatment were significantly higher than those in the control group (P<0.05). At 6 and 12 months after treatment, the levels of PRL, P, FSH, LH and T in the control group were significantly higher than before treatment and observation group, while the levels of E2 were significantly lower than before treatment and observation group(P<0.05). There were no significant differences in the sex hormone levels between the observation group at 3, 6 and 12 months after treatment and before treatment(P>0.05). The incidence of adverse reactions in the observation group was 4.26%, which was significantly lower than that in the control group (21.27%) (P<0.05). Conclusion: Hysteroscopic endometrial resection is effective in the treatment of dysfunctional uterine bleeding, it can significantly improve the anemia status of patients, and it has no significant effect on the sex hormone levels, it has better security. |
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