| 赵月娥,迟 娇,郑 柏,高伟铿,王 萍.高血压患者颈动脉粥样硬化与血脂、血压和血尿酸水平的相关性分析[J].,2019,19(13):2551-2554 |
| 高血压患者颈动脉粥样硬化与血脂、血压和血尿酸水平的相关性分析 |
| Correlation Analysis of Carotid Atherosclerosis and Blood Lipid, Blood Pressure and Serum Uric Acid Level in Patients with Hypertension |
| 投稿时间：2018-11-30 修订日期：2018-12-22 |
| DOI：10.13241/j.cnki.pmb.2019.13.034 |
| 中文关键词: 高血压 颈动脉粥样硬化 血脂 血压 血尿酸 相关性 |
| 英文关键词: Hypertension Carotid atherosclerosis Blood lipid Blood pressure Blood uric acid Correlation |
| 基金项目:海南省基础与应用基础研究计划项目（818MS158） |
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| 中文摘要: |
| 摘要 目的：探讨高血压患者颈动脉粥样硬化（CAS）与血脂、血压以及血尿酸水平的相关性。方法：选择2017年2月至2018年8月在我院就诊的高血压患者117例作为研究组，另选择同期在我院进行体检的健康志愿者50例作为对照组。采用彩色多普勒超声诊断仪测定所有受试者的颈动脉内中膜厚度（IMT），并根据研究组患者的颈动脉IMT将其分为斑块组（IMT≥1.3 mm，33例）、IMT增厚组（1.0 mm≤IMT＜1.3 mm，49例）和IMT正常组（IMT＜1.0 mm，35例）。比较研究组与对照组受试者IMT，同时分别比较研究组与对照组受试者以及不同IMT高血压患者平均收缩压（SBP）、平均舒张压（DBP）、血清总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）以及尿酸水平，并采用Pearson相关性分析法分析高血压患者IMT与各指标的相关性。结果：与对照组比较，研究组IMT、SBP、DBP、TC、TG、LDL-C、血尿酸水平升高，HDL-C水平降低，差异均有统计学意义（P＜0.05）。斑块组患者SBP、DBP、TC、TG、LDL-C、血尿酸水平高于IMT增厚组和IMT正常组，HDL-C水平低于IMT增厚组和IMT正常组，差异均有统计学意义（P＜0.05）；IMT增厚组患者SBP、DBP、TC、TG、LDL-C、血尿酸水平高于IMT正常组，HDL-C水平低于IMT正常组，差异均有统计学意义（P＜0.05）。Pearson相关性分析显示，高血压患者的IMT与SBP、DBP、TC、TG、LDL-C、血尿酸均呈正相关，与HDL-C呈负相关（P＜0.05）。结论：高血压患者IMT与血脂、血压和血尿酸水平均有明显相关性，血压、血脂、血尿酸参与了高血压患者CAS的发生与发展。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the correlation between carotid atherosclerosis (CAS) and blood lipid,blood pressure and serum uric acid levels in patients with hypertension. Methods: 117 patients with hypertension in our hospital from February 2017 to August 2018 were selected as the research group, another 50 healthy volunteers in our hospital during the same period were selected as control group. The carotid artery intima-media thickness (IMT) of all subjects was measured by color Doppler ultrasonography. According to the IMT level of carotid artery in the study group, the patients were divided into plaque group (IMT≥1.3 mm, 33 cases),IMT thickening group (1.0 mm≤IMT< 1.3 mm, 49 cases) and IMT normal group (IMT<1.0 mm, 35 cases). The IMT level of the subjects in the research group and the control group were compared. Meanwhile, the mean systolic blood pressure (SBP), diastolic blood pressure (DBP), serum total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and uric acid levels were compared between the research group and the control group as well as the patients with different IMT hypertension. Pearson correlation analysis was used to analyze the correlation between IMT and indicators in hypertensive patients. Results: Compared with the control group, the levels of IMT, SBP, DBP, TC, TG, LDL-C and uric acid in the research group were obviously higher, while the level of HDL-C was lower, the differences were statistically significant(P<0.05). The levels of SBP, DBP, TC, TG, LDL-C and serum uric acid in plaque group were higher than those in IMT thickening group and IMT normal group. The level of HDL-C was lower than that in the IMT thickening group and IMT normal group, the differences were statistically significant (P<0.05). The levels of SBP, DBP, TC, TG, LDL-C and serum uric acid in IMT thickening group were higher than those in IMT normal group, the level of HDL-C was lower than that in the IMT normal group, the differences were statistically significant (P<0.05). Pearson correlation analysis showed that IMT was positively correlated with SBP, DBP, TC, TG, LDL-C and serum uric acid in patients with hypertension, and it was negatively correlated with HDL-C (P<0.05). Conclusion: There are a significant correlation between IMT and blood lipid, blood pressure and serum uric acid level in patients with hypertension. Blood pressure, blood lipid and blood uric acid are involved in the occurrence and development of CAS in patients with hypertension. |
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