文章摘要
陈 静,王 燕,胡龙妃,李 渝,赵 静.血清胱抑素C、血肌酐及血尿素氮对窒息新生儿肾功能损害的临床意义[J].,2019,19(13):2457-2550
血清胱抑素C、血肌酐及血尿素氮对窒息新生儿肾功能损害的临床意义
Clinical Significance of Serum Cystatin C, Serum Creatinine and Blood Urea Nitrogen on Renal Function Impairment in Neonates with Asphyxia
投稿时间:2018-11-30  修订日期:2018-12-23
DOI:10.13241/j.cnki.pmb.2019.13.033
中文关键词: 新生儿窒息  肾损伤  胱抑素C  血肌酐  血尿素氮  临床意义
英文关键词: Neonatal with asphyxia  Kidney injury  Cystatin C  Serum creatinine  Blood urea nitrogen  Clinical significance
基金项目:重庆市卫生计生委医学科研项目(20151659)
作者单位E-mail
陈 静 重庆医科大学附属第一医院合川医院新生儿科 重庆 401520 jing_jing73@sina.com 
王 燕 重庆医科大学附属永川医院儿科 重庆 402160  
胡龙妃 第三军医大学第三附属医院大坪医院儿科 重庆 400042  
李 渝 重庆医科大学附属第一医院合川医院儿科 重庆 401520  
赵 静 重庆医科大学附属第一医院合川医院新生儿科 重庆 401520  
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中文摘要:
      摘要 目的:探讨血清胱抑素C(Cys C)、血肌酐(SCr)及血尿素氮(BUN)对窒息新生儿肾功能损害的临床意义。方法:选取2013年1月到2018年1月期间重庆医科大学附属第一医院合川医院收治的窒息新生儿200例作为研究组,根据Apgar评分将200例窒息新生儿分为轻度窒息组(128例,Apgar评分:4-7分)和重度窒息组(72例,Apgar评分:0-3分),另选取同期在我院出生的50例足月健康新生儿作为对照组。比较研究组和对照组新生儿血清Cys C、SCr、BUN水平,比较不同窒息程度新生儿血清Cys C、SCr、BUN水平以及Cys C、SCr、BUN的异常率。采用Pearson相关性分析法分析窒息新生儿血清Cys C、SCr、BUN的相关性。结果:研究组血清Cys C、SCr、BUN水平均高于对照组(P<0.05)。重度窒息组血清Cys C、SCr、BUN水平均高于轻度窒息组(P<0.05)。重度窒息组Cys C、BUN的异常率高于轻度窒息组(P<0.05);重度窒息组和轻度窒息组Cys C的异常率高于SCr、BUN的异常率(P<0.05)。Pearson相关性分析结果显示,窒息新生儿Cys C与SCr、BUN均呈正相关,SCr与BUN呈正相关(P<0.05)。结论:窒息新生儿血清Cys C、SCr、BUN水平明显升高,临床可通过检测血清Cys C、SCr、BUN水平来评估窒息新生儿肾损伤情况,且Cys C的评估价值更高。
英文摘要:
      ABSTRACT Objective: To investigate the clinical significance of serum cystatin C (Cys C), serum creatinine (SCr) and blood urea nitrogen (BUN) in renal dysfunction in neonates with asphyxia. Methods: 200 asphyxia neonates who were admitted to the First Affiliated Hospital of Chongqing Medical University and Hechuan Hospital from January 2013 to January 2018 were selected as the study group.According to the Apgar score, 200 neonates with asphyxia were divided into mild asphyxia group (128 cases, Apgar score:4-7) and severe asphyxia group (72 cases, Apgar score: 0-3), and 50 full-term healthy newborns were selected as the control group. The levels of Cys C, SCr and BUN in the neonates of the study group and the control group were compared, and the Cys C, SCr, BUN levels and the abnormal rates of Cys C, SCr and BUN in neonates with different asphyxia levels were compared. Pearson correlation was used to analyze the correlation between the expression of Cys C, SCr and BUN in neonates with asphyxia. Results: The levels of serum Cys C, SCr and BUN in the study group were higher than those in the control group (P<0.05). The serum Cys C, SCr and BUN levels in the severe asphyxia group were higher than those in the mild asphyxia group (P<0.05). The abnormal rates of Cys C and BUN in severe asphyxia group were higher than those in mild asphyxia group (P<0.05). The abnormal rate of Cys C in severe asphyxia group and mild asphyxia group was higher than that in SCr and BUN (P<0.05). Pearson correlation analysis showed that Cys C was positively correlated with SCr and BUN, SCr and BUN were positively correlated (P<0.05). Conclusion: The Cys C, SCr and BUN have certain diagnostic value for renal dysfunction in neonates with asphyxia, but Cys C has the highest value in early diagnosis. The level of Cys C, SCr and BUN can be used to assess renal damage in neonates with asphyxia.
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