| 王金婷,费素娟,钟巧兰,万元春,杨位轩.枯草杆菌二联活菌肠溶胶囊联合康复新液灌肠治疗溃疡性结肠炎的临床疗效[J].,2019,19(13):2519-2522 |
| 枯草杆菌二联活菌肠溶胶囊联合康复新液灌肠治疗溃疡性结肠炎的临床疗效 |
| Clinical Effect of Bacillus Subtilis and Enterococcus Faecium Enteric Capsule Combined with Kangfuxin Solution Enema in the Treatment of Ulcerative Colitis |
| 投稿时间：2018-11-28 修订日期：2018-12-24 |
| DOI：10.13241/j.cnki.pmb.2019.13.027 |
| 中文关键词: 枯草杆菌二联活菌肠溶胶囊 康复新液灌肠 溃疡性结肠炎 疗效 |
| 英文关键词: Bacillus subtilis and enterococcus faecium enteric capsule Kangfuxin solution enema Ulcerative colitis Clinical effect |
| 基金项目:江苏省高校自然科学研究项目(15KJB320001) |
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| 中文摘要: |
| 摘要 目的：探讨枯草杆菌二联活菌肠溶胶囊联合康复新液灌肠治疗溃疡性结肠炎的临床疗效。方法：选取2014年5月~2018年6月淮安市淮阴医院诊治的溃疡性结肠炎患者120例，根据患者入院先后顺序分为两组，对照组在常规治疗的基础上给予枯草杆菌二联活菌肠溶胶囊，观察组在对照组的基础上给予康复新液保留灌肠。比较两组患者的治疗总有效率、治疗前后血清白介素-8(IL-8)、白介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)水平、血小板(PLT)和血酶原时间(PT)、纤维蛋白原(FIB)水平的变化及不良反应的发生情况。结果：治疗后，观察组总有效率为95.00%，对照组为83.33%，观察组显著高于对照组(P<0.05)。两组患者治疗后血清IL-8、IL-6、TNF-α水平及PLT、FIB均较治疗前显著下降，且观察组以上指标均显著低于对照组(P＜0.05)，而两组治疗后PT水平均较治疗前显著升高，且观察组显著高于对照组(P＜0.05)。两组不良反应发生率相比无统计学差异(P＞0.05)。结论：枯草杆菌二联活菌肠溶胶囊联合康复新液灌肠治疗可显著降低溃疡性结肠炎患者的炎性因子水平，改善凝血功能，提高临床治疗效果，且安全性较高。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the clinical effect of bacillus subtilis and enterococcus faecium enteric capsule combined with Kangfuxin solution enema in the treatment of ulcerative colitis. Methods: 120 cases of ulcerative colitis were selected in the huaiyin hospital of huai 'an city from May 2014 to June 2018, and they were divided into two groups according to the sequence of admission. The control group was given the bacillus subtilis and enterococcus faecium enteric capsule on the basis of conventional treatment, and the observation group was given the Kangfuxin solution enema on the basis of control group. The total effective rate, changes of serum IL-8, IL-6, TNF-α, PLT, PT and FIB levels before and after treatment and the incidence of adverse reactions were compared between the two groups. Results: After treatment, the total effective rate of observation group and control group were 95.00% and 83.33%, which was significantly higher in the observation group than that of the control group (P<0.05). After treatment, the levels of serum IL-8, IL-6, TNF-α, PLT and FIB were significantly decreased in both groups compared with before treatment(P＜0.05). The above indexes in the observation group were significantly lower in the observation group than those in the control group (P＜0.05). After treatment, the PT levels in both groups were significantly higher than before treatment, which was significantly higher in the observation group than that of the control group (P＜0.05). There was no statistical difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Bacillus subtilis and enterococcus faecium enteric capsule combined with Kangfuxin solution enema can significantly reduce the level of inflammatory factors, improve the coagulation function and clinical treatment effect in the patients with ulcerative colitis, and it had high security. |
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