文章摘要
高 蕾,李 阔,刘丹丹,崔雯霞,杨海燕,李 曼,胡 云.血清铁蛋白水平与非酒精性脂肪肝的相关性研究[J].,2019,19(13):2481-2485
血清铁蛋白水平与非酒精性脂肪肝的相关性研究
Correlation between Serum Ferritin Level and Nonalcoholic Fatty Liver Disease
投稿时间:2018-12-08  修订日期:2018-12-30
DOI:10.13241/j.cnki.pmb.2019.13.018
中文关键词: 血清铁蛋白  非酒精性脂肪性肝病
英文关键词: Serum ferritin  Nonalcoholic fatty liver disease
基金项目:江苏省卫计委科研基金项目(BJ15005)
作者单位E-mail
高 蕾 南京大学医学院附属鼓楼医院老年科 江苏 南京 210008 gaolei706@163.com 
李 阔 南京大学医学院附属鼓楼医院老年科 江苏 南京 210008  
刘丹丹 南京大学医学院附属鼓楼医院老年科 江苏 南京 210008  
崔雯霞 南京大学医学院附属鼓楼医院老年科 江苏 南京 210008  
杨海燕 南京大学医学院附属鼓楼医院老年科 江苏 南京 210008  
李 曼 南京大学医学院附属鼓楼医院老年科 江苏 南京 210008  
胡 云 南京大学医学院附属鼓楼医院老年科 江苏 南京 210008  
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中文摘要:
      摘要 目的:探讨血清铁蛋白水平与非酒精性脂肪肝(nonalcoholic fatty liver disease,NAFLD)的相关性。方法:选择2016年10月至2017年4月我院干保中心诊治的患者299例,根据腹部超声分为有NAFLD组及无NAFLD组。空腹抽血检测肝酶、血脂、血糖、胰岛素、血清铁蛋白、血常规。Pearson相关分析血清铁蛋白与各代谢指标的关系,采用Logistic二元回归分析血清铁蛋白水平与非酒精性脂肪肝患病率的关系。结果:NAFLD组血清铁蛋白水平明显高于非NAFLD组(301.9±206.2 ng/mL vs. 176±125.6 ng/mL,P<0.05)。血清铁蛋白水平与腹围、体重指数、血红蛋白、谷丙转氨酶、甘油三酯显著正相关(P<0.05),与高密度脂蛋白胆固醇显著负相关(P<0.05)。根据血清铁蛋白从低到高分成4等分,Q1(17.8-124.8 ng/mL)、Q2(125.6-199.4 ng/mL)、Q3(200.1-339.1 ng/mL)、Q4(345.6-1074.9 ng/mL),其对应的NAFLD患病率分别为37.3%、52.0%、70.7%、78.4%,组间比较差异有统计学意义(P<0.05)。将血清铁蛋白第一分位患脂肪肝的OR设为1.00,校正年龄、性别、体重指数、血红蛋白、甘油三酯、高密度脂蛋白胆固醇后,第二至第四分位的OR(95%CI)分别为1.994(0.908-4.379),3.334(1.464-7.595),3.954(1.578-9.907) (趋势P<0.05)。结论:血清铁蛋白水平与NAFLD发病明显相关,血清铁蛋白水平升高时,NAFLD的发病风险增加。
英文摘要:
      ABSTRACT Objective: To investigate the correlation of serum ferritin level with nonalcoholic fatty liver disease (NAFLD). Methods: 299 cases of patients admitted in the Nanjing Drum Tower Hospital from October 2016 to April 2017 were selected and divided into the NAFLD group and the non NAFLD group according to abdominal ultrasound. The relationship between serum ferritin and various metabolic parameters was analyzed by Pearson correlation analysis and the relationship between serum ferritin and non-alcoholic fatty liver disease rate was analyzed by Logistic regression analysis. Results: The serum ferritin level in group NAFLD was significantly higher than that in non NAFLD Group ((301.9±206.2 ng/mL vs. 176±125.6) ng/mL, P<0.05). There was a positive correlation between serum ferritin and waist circumference, BMI, Hb, ALT and TG (P < 0.05), and negatively correlated with HDL-C (P < 0.05). 299 subjects were divided into 4 groups according to the serum ferritin quartiles. which were Q1 (17.8-124.8 ng/mL), Q2 (125.6-199.4 ng/mL), Q3 (200.1-339.1 ng/mL), Q4 (345.6-1074.9 ng/mL). The corresponding NAFLD prevalence was 37.3%, 52%, 70.7% and 78.4%. The difference between groups was statistically significant (P<0.05). After correction of age, sex, BMI, Hb, TG, HDL-C, when compared with the first quartile of serum ferritin(reference 1.00) the odds ratio(OR) and 95%confidence interval(CI)for NAFLD across increasing quartiles of serum ferritin were 1.994 (0.908-4.379), 3.334 (1.464-7.595), 3.954 (1.578-9.907) respectively(P for trend<0.05). Conclusion: Serum ferritin level was significantly associated with the onset of NAFLD, and when serum ferritin level is elevated, the risk of NAFLD increases.
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