| 张细庆,陈文玲,胡月娇,万 萍,付婷婷,唐丽娟.NGF蛋白及前列腺F2α受体与子宫腺肌病痛经的相关性研究[J].,2019,19(11):2155-2158 |
| NGF蛋白及前列腺F2α受体与子宫腺肌病痛经的相关性研究 |
| A Study on the Correlation of NGF Protein and Prostate F2α receptor in the Adenomyosis Dysmenorrhea |
| 投稿时间：2018-11-27 修订日期：2018-12-23 |
| DOI：10.13241/j.cnki.pmb.2019.11.033 |
| 中文关键词: 子宫腺肌病 痛经 神经生长因子蛋白 前列腺F2α受体 相关性 |
| 英文关键词: Uterine adenomyosis Dysmenorrhea. Nerve growth factor protein Prostate F2 α receptor Correlation |
| 基金项目:江西省自然科学基金项目(2013BA20501) |
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| 中文摘要: |
| 摘要 目的：研究NGF蛋白及前列腺F2?琢受体(PTGFR)与子宫腺肌病痛经的相关性。方法：选择我院2016年7月~2017年7月收治的36例子宫腺肌病痛经患者，按视觉模拟评分法(VAS)将痛经程度分为11例轻度组、14例中度组、11例重度组。同期选择36例月经正常者作为对照组。比较各组血清NGF蛋白和血浆PTGFR水平，分析二者和痛经评分之间的相关性及其单独和联合检测时诊断子宫腺肌病痛经的敏感性、特异性及受试者工作特征(ROC)曲线下面积。结果：子宫腺肌病痛经组血清NGF蛋白和血浆PTGFR水平均显著高于对照组(P<0.05)。轻度痛经组血清NGF蛋白及血浆PTGFR水平均显著低于中度组和重度组(P<0.05)。血清NGF蛋白和血浆PTGFR水平和子宫腺肌病痛经评分均呈显著正相关，r分别为0.812，0.884(P<0.05)。ROC曲线分析结果显示血清NGF蛋白联合血浆PTGFR蛋白检测诊断子宫腺肌病痛经的ROC曲线下面积明显大于血清NFG蛋白及血浆PTGFR水平单独检测(P<0.05)。结论：NGF蛋白和PTGFR可能参与了子宫腺肌病痛经的发生和发展，二者联合检测有助于诊断子宫腺肌病痛经。血清NGF蛋白水平及血浆PTGFR蛋白水平和子宫腺肌病痛经程度呈正相关。 |
| 英文摘要: |
| ABSTRACT Objective: To study the correlation of NGF protein and prostate F2?琢 receptor in the adenomyosis dysmenorrhea. Methods: 36 cases of uterine adenomyosis dysmenorrhea patients who received therapy from July 2016 to July 2016 in our hospital were treated, according to the visual analogue scale (VAS) score, those patients were divided into 11 cases in the mild groups, 14 cases in the moderate groups and 11 cases in the severe groups. In the same period, 36 patients were selected as the control group. The serum levels of NGF protein and plasma PTGFR were compared between different groups, and the correlation between them and dysmenorrhea score as well as the sensitivity, specificity and area under the ROC curve for the diagnosis of dysmenorrhea in adenomyosis when detected alone or in combination were analyzed. Results: The levels of serum NGF protein and plasma PTFFR in the dysmenorrhea group were significantly higher than those in the control group (P<0.05). The levels of serum NGF protein and plasma PTFFR in the mild dysmenorrhea group were significantly lower than those in the moderate group, and lower than the severe group (P<0.05). Serum levels of NGF protein and plasma PTFFR were significantly positively correlated with uterine adenomyosis dysmenorrhea scores, r were 0.812, 0.884(P<0.05). The ROC curve analysis showed that the area under the ROC curve of serum NGF protein combined with plasma PTFFR protein in the diag- nosis of adenomyosis was significantly greater than that of serum NFG protein and plasma PTFFR (P<0.05). Conclusion: NGF protein and PTFFR may be involved in the occurrence and development of dysmenorrhea in adenomyosis. Combined detection of NGF protein and PTFFR may help to diagnose THE dysmenorrhea of adenomyosis. Serum levels of NGF protein and plasma PTGFR protein were positively correlated with the uterine adenomyosis. |
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