| 邰迎春,赵爱妮,王 晶,赵丽华,孙丽娜.丙种球蛋白联合地屈孕酮治疗复发性流产的效果及对患者免疫功能和血清炎症因子水平的影响[J].,2019,19(11):2112-2115 |
| 丙种球蛋白联合地屈孕酮治疗复发性流产的效果及对患者免疫功能和血清炎症因子水平的影响 |
| Effect of Gamma Globulin Combined with Megestrol Acetate on the Recurrent Spontaneous Abortion and Its Influence on the Immune Function and Serum Inflammatory Cytokines Levels |
| 投稿时间：2018-11-07 修订日期：2018-11-30 |
| DOI：10.13241/j.cnki.pmb.2019.11.023 |
| 中文关键词: 丙种球蛋白 地屈孕酮 复发性流产 疗效 血清细胞因子 免疫功能 |
| 英文关键词: Gamma globulin Megestrol acetate Recurrent spontaneous abortion Curative effect Serum cytokines Immunologic function |
| 基金项目:陕西省自然科学基础研究计划项目(2010JQ4008) |
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| 中文摘要: |
| 摘要 目的：探讨丙种球蛋白联合地屈孕酮治疗复发性流产的效果及对患者免疫功能和血清炎症因子水平的影响。方法：选择2016年1月-2017年12月我院收治的82例复发性流产患者为研究对象，将其随机分为两组。对照组采用单纯口服地屈孕酮，每次10 mg，每天2次；观察组在对照组基础上联合静脉滴注丙种球蛋白500 mg/(kg?d)。比较两组治疗前后的血清白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)以及白介素-10(IL-10)水平，CD4+/CD8+、CD8+以及CD4+及保胎成功率。结果：治疗后，观察组治愈14例，有效18例，无效9例，治疗有效率为78.05%(32/41)，明显高于对照组[60.98%(25/41)](P<0.05)；两组治疗后的血清TNF-α、CD8+水平较治疗前明显降低(P<0.05)，血清IL-6、IL-10、CD4+/CD8+以及CD4+水平较治疗前明显升高(P<0.05)，且观察组血清TNF-α、CD8+水平明显低于对照组(P<0.05)，血清IL-6、IL-10、CD4+/CD8+以及CD4+水平明显高于对照组(P<0.05)。观察组的保胎成功率为82.93%(34/41)，明显高于对照组[31.71%(13/41)](P<0.05)。结论：丙种球蛋白联合地屈孕酮可以有效增强复发性流产患者体内的免疫功能，减少调节炎症因子的表达，提高保胎成功率. |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of gamma globulin combined with megestrol acetate in the treatment of recurrent spontaneous abortion and its influence on immune function and serum inflammatory factors. Methods: 82 patients with recurrent sponta- neous abortion admitted to our hospital from January 2016 to December 2017 were randomly divided into two groups. The control group was treated with oral megestrol acetate only, and the observation group was given intravenous gamma globulin [500 mg/(kg?d)] on the basis of the control group. The serum levels of IL-6, TNF-α and IL-10, CD4+/CD8+, CD8+, CD4+, and the success rate of pregnancy preservation were compared between the two groups. Results: After treatment, 14 cases were cured, 18 cases were effective and 9 cases were ineffective in the observation group. The effective rate was 78.05%(32/41), which was significantly higher than that in the control group [60.98% (25/41)](P<0.05). And the levels of serum TNF-α and CD8+ in the two groups were significantly lower than those be- fore treatment (P<0.05), the levels of serum IL-6, IL-10, CD4+/CD8+ and CD4+ were significantly higher than those before treatment(P<0.05). The levels of serum TNF-α and CD8+ in the observation group were significantly lower than those in the control group(P<0.05). The levels of serum IL-6, IL-10, CD4+/CD8+ and CD4+ in the observation group were significantly higher than those in the control group(P<0.05). The success rate of the observation group was 82.93%(34/41), which was significantly higher than that of the control group[31.71% (13/41)](P<0.05). Conclusion: Gamma globulin combined with megestrol acetate can effectively enhance the immune function of patients with recurrent spontaneous abortion, reduce the expression of inflammatory factors, and improve the success rate of pregnancy preservation. |
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