| 沈 珺,黄菲菲,何海燕,陈金梅,张 杰.老年帕金森患者肺功能变化及其与炎性因子的相关性[J].,2019,19(10):1879-1882 |
| 老年帕金森患者肺功能变化及其与炎性因子的相关性 |
| Correlation of Changes of Lung Function and Inflammatory Cytokines in Elderly Patients with Parkinson's Disease |
| 投稿时间：2018-10-28 修订日期：2018-11-21 |
| DOI：10.13241/j.cnki.pmb.2019.10.015 |
| 中文关键词: 帕金森 老年 肺功能 炎性因子 |
| 英文关键词: Parkinson's disease Elderly Lung function Inflammatory cytokines |
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| 中文摘要: |
| 摘要 目的：检测老年帕金森(PD)患者肺功能的变化及血清炎性因子的表达并分析二者的相关性。方法：选择2015年1月~2017年12月上海交通大学医学院附属第九人民医院神经内科收治的74例老年PD患者作为PD组，并选择相同时期在我院体检中心接受健康体检的正常体检者50例作为对照组。检测和比较其肺功能指标如用力肺活量(FVC)、第一秒用力呼气容积(FEV1)及FEV1/FVC以及血清白介素1β(IL-1β)、IL-6、IL-12、肿瘤坏死因子-α(TNF-α)水平的变化。根据Hoehn-Yahr分级将患者分为轻中度(1.0~3.0，45例)、重度(4.0~5.0，29例)。分析和比较各组PD患者肺功能与血清炎性因子水平的相关性。结果：与对照组比较，轻中度、重度PD组FVC、FEV1水平明显降低，重度PD组FVC、FEV1、FEV1/FVC明显低于轻中度PD组(P<0.05)。与轻中度组比较，重度组阻塞性、限制性通气功能障碍的发生率明显升高(P<0.05)。重度PD组血清IL-1β、IL-6、IL-12、TNF-α水平显著高于对照组与轻中度PD组(P<0.05)。轻中度组患者FVC、FEV1与IL-1β、TNF-α均呈显著负相关(P<0.05)，重度组患者FVC、FEV1、FEV1/FVC与IL-1β、IL-6、IL-12、TNF-α均呈显著负相关(P<0.05)。结论：老年PD患者存在不同程度的肺功能减退，且与PD病情及血清炎性因子水平密切相关，改善肺功能及减少炎性因子的表达可能有助于缓解PD的病情进展。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the changes of lung function and expression of serum inflammatory cytokines in elderly patients with Parkinson's disease(PD), and explore the correlation between the lung function and inflammatory cytokines. Methods: 74 cases of patients with PD who were treated in the department of Neurology, the Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine from January 2015 to December 2017(PD group) and 50 cases of healthy physical examination in the physical examination center of our hospital at the same time(control group) were selected. The PD patients were divided into two groups according to Hoehn-Yahr, including mild and moderate group (1.0~3.0, 45 cases) and severe lung injury group (4.0~5.0, 29 cases). The lung function indicators such as forced lung capacity (FVC), forced expiratory volume (FEV1) and FEV1/FVC, as well as serum interleukin-1β(IL-1β), IL-6, IL-12, tumor necrosis factor-α(TNF-α) were detected and compared between two groups. The correlation between lung function and serum inflammatory cytokines was analyzed. Results: Compared with the control group, the levels of FVC, FEV1 in mild and moderate PD group and severe PD group were decreased significantly, the levels of FVC, FEV1, FEV1/FVC in severe PD group were also decreased significantly compared with those of the mild and moderate PD group (P<0.05). Compared with the mild and moderate PD group, the incidence of obstructive, restrictive ventilatory dysfunction in severe PD group was increased significantly (P<0.05). The levels of serum IL-1β, IL-6, IL-12, TNF-α levels in severe PD group were higher significantly than those in the control group and the mild and moderate PD group (P<0.05). The FVC, FEV1 in mild to moderate group were significantly negative correlated with the serum IL-1β and TNF-α levels (P<0.05). There was significant correlation between FVC, FEV1, FEV1/FVC in patients with severe group with serum IL-1β, IL-6, IL-12, TNF-α levels (P<0.05). Conclusion: There were different degrees of lung function impairment in elderly patients with PD, and is correlated with the severity and expression of inflammatory cytokines, they may be involved in the occurrence and development of PD. |
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