| 陈 鹏,庞健健,付 慧,李雅茹,李 斌.重症肺炎患者血清氧化应激指标和炎症因子的表达及其与肺部感染评分的关系[J].,2019,19(9):1778-1781 |
| 重症肺炎患者血清氧化应激指标和炎症因子的表达及其与肺部感染评分的关系 |
| Expression of Serum Oxidative Stress Indexes and Inflammatory Factors in Patients with Severe Pneumonia and Their Relationship with Pulmonary Infection Score |
| 投稿时间：2019-01-23 修订日期：2019-02-18 |
| DOI：10.13241/j.cnki.pmb.2019.09.039 |
| 中文关键词: 重症肺炎 氧化应激 炎症因子 CPIS评分 相关性 |
| 英文关键词: Severe pneumonia Oxidative stress Inflammatory factors CPIS score Correlation |
| 基金项目:陕西省教育厅专项科研计划项目（18JK0673）；陕西省科技厅自然科学基金项目（2018JM7069）；陕西省呼吸病预防与诊治工程研究中心开放基金项目（2017HXKF03） |
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| 中文摘要: |
| 摘要 目的：探讨重症肺炎患者血清氧化应激指标和炎症因子的表达及其与肺部感染评分（CPIS）的关系。方法：选取2016年1月到2018年12月在西安市胸科医院接受治疗的重症肺炎患者120例作为观察组，另选取同期在该院接受治疗的普通肺炎患者120例作为对照组。比较两组患者血清中的炎症因子指标、氧化应激指标和CPIS评分，分析重症肺炎患者炎症因子指标、氧化应激指标与CPIS评分的相关性。结果：观察组患者血清中白介素-6（IL-6）、白介素-18（IL-18）、肿瘤坏死因子-α（TNF-α）水平明显高于对照组，差异具有统计学意义（P<0.05），观察组患者血清中过氧化脂质（LPO）水平高于对照组，血清中超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）水平低于对照组，差异具有统计学意义（P<0.05），观察组患者的CPIS评分高于对照组（P<0.05）。Pearson相关分析结果显示：重症肺炎患者的CPIS评分与IL-6、IL-18、TNF-α、LPO水平呈正相关（P<0.05），与SOD、GSH-Px水平呈负相关（P<0.05）。结论：重症肺炎患者存在明显的炎症反应和氧化应激反应，且炎症反应和氧化应激反应的程度和患者肺部感染程度密切相关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between the expression of serum oxidative stress indexes and inflammatory factors in patients with severe pneumonia and their relationship with pulmonary infection score (CPIS). Methods: 120 patients with se- vere pneumonia who were treated in Xi'an Chest Hospital from October 2017 to September 2018 were selected as the observation group. Another 120 patients with common pneumonia who were treated in the hospital during the same period were selected as the control group. The inflammatory factors, oxidative stress indexes and CPIS score were compared between the two groups. The correlation be- tween inflammatory factors and oxidative stress indexes and CPIS score in patients with severe pneumonia were analyzed. Results: The levels of serum interleukin-6 (IL-6), interleukin-18 (IL-18) and tumor necrosis factor-α (TNF-α) in the observation group were signifi- cantly higher than those in the control group, and the difference was statistically significant (P<0.05). The levels of serum lipid peroxida- tion (LPO) in the observation group was higher than that of the control group, the levels of serum superoxide dismutase (SOD) and glu- tathione peroxidase (GSH-Px) were lower than those of the control group, and the difference was statistically significant (P<0.05). The CPIS score of the observation group was higher than that of the control group (P<0.05). The results of Pearson correlation analysis show that the CPIS scores in patients with severe pneumonia was positively correlated with the levels of IL-6, IL-18, TNF-α and LPO (P<0.05), which was negatively correlated with the levels of SOD and GSH-Px (P<0.05). Conclusion: Severe pneumonia patients have obvious in- flammatory reaction and oxidative stress reaction,and the degree of inflammation and oxidative stress is closely related to the degree of pulmonary infection. |
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