| 陈寒冬,吴立海,苗 亮,闫 晶,张 英,郎晓林,郑 岳,董敬超.HIV感染患者血清IL-2、IL-16水平和CD4细胞计数的相关性分析[J].,2019,19(9):1758-1761 |
| HIV感染患者血清IL-2、IL-16水平和CD4细胞计数的相关性分析 |
| Correlative Analysis of the Serum il-2, il-16 Levels with CD4 Cell Counts in the HIV-infected Patients |
| 投稿时间：2018-11-23 修订日期：2018-12-18 |
| DOI：10.13241/j.cnki.pmb.2019.09.034 |
| 中文关键词: 人类免疫缺陷病毒 白细胞介素-2 白细胞介素-16 CD4细胞计数 相关性 |
| 英文关键词: Human immunodeficiency virus Interleukin-2 Interleukin-16 CD4 cell count The correlation |
| 基金项目:河北省科技技术研究与发展计划项目(12277746)；秦皇岛市科学技术研究与发展计划(201703A091) |
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| 中文摘要: |
| 摘要 目的：探讨人类免疫缺陷病毒(HIV)感染患者血清白细胞介素-2(IL-2)、白细胞介素-16(IL-16)水平和CD4细胞计数的相关性。方法：选择2017年3月至2018年3月我院接诊的50例HIV感染患者作为观察组及同期于我院进行体检的健康人群40例作为对照组。检测和比较两组血清IL-2、IL-16与CD4细胞计数，并分析观察组血清IL-2、IL-16与CD4细胞计数的相关性。结果：观察组患者血清IL-2、IL-16水平及CD4细胞计数显著低于对照组，差异具有统计学意义(P<0.05)；Pearson相关分析结果显示观察组患者血清IL-2、IL-16水平与CD4细胞计数呈显著正相关(r=0.514，r=0.499，P<0.05)。结论：HIV感染患者血清IL-2、IL-16水平显著下调，并与CD4细胞计数呈显著正相关，可在一定程度上反映HIV感染的严重度。 |
| 英文摘要: |
| ABSTRACT Objective: To study Analysis of the Correlation between serum il-2, il-16 levels and CD4 cell counts in hiv-infected patients. Methods: 50 patients with HIV infection admitted to our hospital from March 2017 to March 2018 were selected as the observa- tion group and 40 healthy people who underwent physical examination in our hospital during the same period as the control group, the serum il-2, il-16 and CD4 cell counts in the two groups were detected and compared, and the correlation between serum il-2, il-16 and CD4 cell counts in the observation group was analyzed. Results: Serum il-2, il-16 levels and CD4 cell counts in the observation group were significantly lower than those in the control group, with statistically significant differences (P<0.05). Pearson correlation analysis showed that serum il-2 and il-16 levels in the observation group were significantly positively correlated with CD4 cell count (r=0.514, r=0.499, P<0.05). Conclusion: Serum il-2 and il-16 levels of hiv-infected patients were significantly down-regulated and positively corre- lated with CD4 cell count, which can reflect the severity of HIV infection to some extent. |
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