| 鲁 欣,吉 清,周 倩,段丽霞,任 田,彭贵勇.一种新型国产内镜射频消融治疗仪对胃食管反流病的疗效[J].,2019,19(9):1697-1701 |
| 一种新型国产内镜射频消融治疗仪对胃食管反流病的疗效 |
| Efficacy of a New Domestic Radiofrequency Ablation Instrument for Gastroesophageal Reflux Disease |
| 投稿时间：2018-10-25 修订日期：2018-11-21 |
| DOI：10.13241/j.cnki.pmb.2019.09.020 |
| 中文关键词: 射频消融 胃食管反流病 生活质量 疗效 |
| 英文关键词: Radiofrequency ablation Gastroesophageal reflux disease Quality of life Curative effect |
| 基金项目:第三军医大学第一附属医院重大领域技术创新项目(SWH2016ZDCX3011)；国家自然科学基金项目(81470907)；重庆市社会民生科技创新专项(cstc2015shmszx10017) |
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| 中文摘要: |
| 摘要 目的：探讨一种新型国产内镜射频消融治疗仪对胃食管反流病(GERD)的疗效。方法：选取2016年6月-2017年6月来我院就诊的难治性GERD患者50例，随机分为内镜射频治疗组(美顿Medi?射频治疗仪，n=25)与药物治疗组(n=25)。比较两组患者干预前后的酸反流严重程度、胃食管反流病自测量表(GerdQ)评分、质子泵抑制剂(PPI)的药物使用率、简明健康调查量表(SF-36)评分。结果：（1）内镜射频治疗组患者干预后即刻的胃镜提示射频消融治疗区域的消化道黏膜出现收缩、增厚，干预后6、12个月分别有15例(60.0%)、20例(80.0%)的食管下段黏膜的充血带较前减少。（2）两组干预后3、12个月的GerdQ总分均显著低于干预前(P＜0.05)，内镜射频治疗组干预后3、12个月的GerdQ总分均显著低于同期药物治疗组(P＜0.05)。（3）全部患者干预前均需要药物来缓解症状，内镜射频治疗组干预3、12个月时的PPI药物使用率均显著低于药物治疗组(P＜0.05)。（4）内镜射频治疗组干预后SF-36的生理职能、生命活力、精神状态、总体健康等维度评分均显著高于同期药物治疗组(P＜0.05)。结论：美顿Medi?射频治疗仪对GERD患者是一种安全、有效的治疗选择，能显著改善反流症状，减少PPI药物使用，提高患者的生活质量。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the efficacy of a new domestic radiofrequency ablation instrument for gastroesophageal re- flux disease (GERD). Methods: 50 patients with refractory GERD in our hospital from June 2016 to June 2017 were enrolled for the study and randomly divided into endoscopic radiofrequency therapy group (Medi? radiofrequency instrument, n=25) and drug treatment group (n=25). The severity of acid reflux, gastroesophageal reflux disease questionnaire (GerdQ) score, proton pump inhibitors (PPI) drug use rate and Short Form 36 Health Survey Scale (SF-36) score were compared between two groups before and after intervention. Results: (1)Gastroscopy immediately after intervention in endoscopic radiofrequency therapy group indicated that the gastrointestinal mucosa in the radiofrequency ablation treatment area contracted and thickened. At 6 and 12 months after intervention, the congestion zone of lower esophageal mucosa of 15 (60.0%) and 20 (80.0%) patients significantly decreased. (2)The total score of GerdQ at 3 and 12 months after intervention in two groups were significantly lower than those before intervention (P<0.05). The total score of GerdQ at 3 and 12 months after intervention in endoscopic radiofrequency therapy group were significantly lower than those in drug treatment group (P<0.05). (3)All patients need drugs to alleviate symptoms before interventio. The PPI drug use rate in endoscopic radiofrequency therapy group at 3 and 12 months of intervention were significantly lower than those in drug treatment group (P<0.05). (4)The scores of physiological func- tion, life vitality, mental state and general health of SF-36 in endoscopic radiofrequency therapy group were significantly higher than those in drug treatment group (P<0.05). Conclusion: Medi? radiofrequency instrument is a safe and effective treatment choice for GERD patients. It could significantly improve reflux symptoms, reduce the use of PPI drugs and improve patients' quality of life. |
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