| 荆仕娟,周 伟,张智敏,王昱景,黄 巍,李 杨.不同剂量雷公藤多苷联合复方丹参对过敏性紫癜性肾炎患者凝血功能及内皮细胞功能的影响[J].,2019,19(9):1692-1696 |
| 不同剂量雷公藤多苷联合复方丹参对过敏性紫癜性肾炎患者凝血功能及内皮细胞功能的影响 |
| Effects of Different doses of Tripterygium Glycoside Combined with Compound Salvia Miltiorrhiza on Coagulation Function and Endothelial cell Function in Patients with Henoch-Schonlein Purpura Nephritis |
| 投稿时间：2018-09-12 修订日期：2018-09-30 |
| DOI：10.13241/j.cnki.pmb.2019.09.019 |
| 中文关键词: 过敏性紫癜肾炎 凝血功能 内皮细胞功能 雷公藤多苷 复方丹参 |
| 英文关键词: Henoch-Schonlein purpura nephritis Coagulation function Endothelial cell function Tripterygium glycoside Compound salvia miltiorrhiza |
| 基金项目:全军医学科技创新计划项目（SWH2017134） |
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| 中文摘要: |
| 摘要 目的：考察不同剂量雷公藤多苷联合复方丹参对过敏性紫癜性肾炎（HSPN）患者凝血功能及内皮细胞功能的影响，并评价疗效。方法：选取我院2016年9月至2018年3月收治的72例HSPN患者，按照随机数字表法分成对照组（静脉滴注复方丹参注射液治疗）、低剂量组（1.0 mg/kg雷公藤多苷联合复方丹参注射液治疗）和高剂量组（1.5 mg/kg雷公藤多苷联合复方丹参注射液治疗），每组各24例，三组均治疗12周。分别于治疗前后检测三组患者凝血酶原时间（PT）、凝血酶时间（TT）、纤维蛋白原（FIB）水平、活化部分凝血活酶时间（APPT）、血小板计数（PLT）、内皮细胞生长因子（VEGF）、内皮素-1（ET-1）水平及血流介导的血管扩张功能（FMD）。评价三组疗效，并观察治疗过程中出现的不良反应。结果：治疗后低剂量组、高剂量组TT、APPT较治疗前和对照组明显升高，FIB和PLT明显降低，且高剂量组较低剂量组变化更明显（P<0.05），治疗后高剂量组PT高于治疗前、对照组和低剂量组（P<0.05）。治疗后低剂量组、高剂量组VEGF及ET-1水平较治疗前降低，FMD值较治疗前升高，且高剂量组VEGF及ET-1水平低于对照组和低剂量组，FMD值高于对照组和低剂量组（P<0.05）。高剂量组的有效率为95.83%（23/24），高于低剂量组的75.00%（18/24）和对照组的42.67%（10/24）。三组不良反应发生率无明显差异（P>0.05）。结论：高剂量雷公藤多苷与复方丹参注射液合用较低剂量的合用可明显改善HSPN患者的凝血功能并恢复内皮细胞功能，疗效明显，安全性高。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of different doses of Tripterygium glycoside combined with compound salvia mil- tiorrhiza on coagulation function and endothelial cell function in patients with Henoch-Schonlein purpura nephritis,and to evaluate the curative effect. Methods: 72 patients with HSPN admitted to our hospital from September 2016 to March 2018 were selected. They were divided into control group (intravenous drip of compound salvia miltiorrhiza injection), low dose group (1.0 mg/kg Tripterygium glyco- side combined with compound salvia miltiorrhiza injection) and high dose group (1.5 mg/kg Tripterygium glycoside combined with com- pound salvia miltiorrhiza injection) according to the random number table method, 24 cases in each group, and the three groups were treated for 12 weeks. The prothrombin time (PT), thrombin time (TT), fibrinogen (FIB), activated partial prothrombin time (APPT), platelet (PLT), vascular endothelial growth factor (VEGF), endothelin-1 (ET-1) and flow-mediated dilation (FMD) were measured before and after treatment. The efficacy of the three groups were evaluated, and adverse reactions during treatment were observed. Results: After treatment, TT and APPT in low dose group and high dose group were significantly increased, FIB and PLT were significantly decreased, and the changes in high dose group than low dose group were more obvious (P<0.05). After treatment, PT in high dose group was higher than before treatment, control group and low dose group(P<0.05). After treatment, the levels of VEGF and ET-1 in low dose group and high dose group were lower than those before treatment, and FMD was higher than those before treatment.The levels of VEGF and ET-1 in high dose group were lower than those in control group and low dose group, and FMD was higher than that in control group and low dose group (P<0.05). The effective rate in high dose group was 95.83% (23/24), higher than 75.00% (18/24) in low dose group and 42.67% (10/24) in control group. There was no significant difference in the incidence of adverse reactions between the three groups (P>0.05). Conclusion: High dose Tripterygium glycoside combined with compound salvia miltiorrhiza injection can significantly improve coagula- tion function and restore endothelial cell function compared with low dose in patients with HSPN, with obvious curative effect and high safety. |
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