| 胥 军,吴建中,姜海燕,唐建平,仓 彦.冠心病患者心率变异性与冠状动脉病变狭窄范围及严重程度的关系研究[J].,2019,19(9):1679-1682 |
| 冠心病患者心率变异性与冠状动脉病变狭窄范围及严重程度的关系研究 |
| Relationship between Heart Rate Variability and Range of Stenosis and Severity of Coronary Artery Stenosis in Patients with Coronary Heart Disease |
| 投稿时间：2018-09-27 修订日期：2018-10-21 |
| DOI：10.13241/j.cnki.pmb.2019.09.016 |
| 中文关键词: 心率变异性 冠状动脉狭窄 冠心病 狭窄程度 狭窄范围 |
| 英文关键词: Heart rate variability Coronary artery stenosis Coronary heart disease Severity of stenosis Range of stenosis |
| 基金项目:上海市卫计委基金项目(2015SY384) |
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| 中文摘要: |
| 摘要 目的：探讨冠心病患者心率变异性（HRV）与冠状动脉病变狭窄范围及严重程度的关系。方法：选取上海市第十人民医院2015年1月至2018年7月期间收治的冠心病患者220例，所有患者均行冠脉造影及24 h动态心电图检查。按狭窄范围分为单支狭窄组（n=68）、双支狭窄组（n=82）、三支狭窄组（n=70），按狭窄严重程度分为轻度组（狭窄≤50%，n=62），中度组（50%<狭窄<70%，n=66），重度组（狭窄≥70%，n=92），另选取51例同期于我院体检的健康志愿者作为对照组。记录冠心病患者与对照组HRV各项指标，比较不同冠脉病变狭窄范围患者、不同狭窄严重程度患者正常平均N-N间期（SDNN）、正常相邻每5minR-R间期均数标准差（SDANN）、正常相邻正常N-N间期的均方根（RMSSD）、正常相邻间期差值高于50 ms心搏数占总心搏数的百分比（pNN50）、低频（LF）、高频（HF）及低频/高频比值（LF/HF）。结果：冠心病患者与对照组RMSSD、pNN50、LF、HF比较差异无统计学意义（P>0.05），冠心病患者SDNN、SDANN低于对照组，LF/HF值高于对照组（P<0.05）。不同冠脉狭窄范围、不同冠脉病变狭窄严重程度患者pNN50、LF、HF整体比较无统计学差异（P>0.05），随着冠脉狭窄范围的增加或狭窄病变严重程度的加重SDDN、SDANN、RMSSD逐渐降低，LF/HF值逐渐升高（P<0.05）。结论：HRV是评估心脏自主功能的良好指标，该指标中SDDN、SDANN、RMSSD、LF/HF值可作为评估冠心病患者冠状动脉的狭窄程度和狭窄范围的良好指标，具有重要的临床指导意义。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between heart rate variability (HRV) and the range of stenosis and severity of coronary artery stenosis in patients with coronary heart disease. Methods: 220 patients with coronary heart disease who were admitted to Shanghai Tenth People's Hospital from January 2015 to July 2018 were selected,all patients underwent coronary angiography and 24-hour dynamic electrocardiogram examination. They were divided into single-vessel stenosis group (68 cases), double-vessel stenosis group (82 cases) and three-vessel stenosis group (70 cases) according to the range of stenosis. They were divided into mild group (steno- sis≤50%, n=62), moderate group (50%Results: There were no significant differences in RMSSD, pNN50, LF and HF between the patients with coronary heart disease and the control group (P>0.05). The SDNN and SDANN of patients with coronary heart disease were lower than those of the control group, and the LF/HF value was higher than that of the control group (P<0.05). There were no significant differences in pNN50, LF and HF among patients with different coronary stenosis range and severity (P>0.05). With the increase of coronary stenosis or the severity of the severity of coronary stenosis, the SDDN,SDANN and RMSSD decreased gradually, the LF/HF value gradually increased(P<0.05). Conclusion: HRV is a good indica- tor for assessing cardiac autonomic function, the values of SDDN, SDANN, RMSSD and LF/HF can be used as a good index to evaluate the degree and range of coronary artery stenosis in patients with coronary heart disease, which have important clinical guiding significance. |
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