| 林 烨,裴 培,王 珊.组蛋白泛素化与去泛素化对染色质和基因表达的研究进展[J].,2019,19(8):1578-1582 |
| 组蛋白泛素化与去泛素化对染色质和基因表达的研究进展 |
| Progress in Histone Ubiquitination and Deubiquitination with Chromatin Homeostasis and Gene Expression Regulation |
| 投稿时间：2018-06-06 修订日期：2018-06-28 |
| DOI：10.13241/j.cnki.pmb.2019.08.040 |
| 中文关键词: 组蛋白 泛素化 去泛素化 染色质稳态 基因调控 |
| 英文关键词: Histone Ubiquitination Deubiquitination Chromatic homeostasis Regulation of gene expression |
| 基金项目:国家自然科学基金项目（81771584） |
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| 中文摘要: |
| 摘要：组蛋白或转录因子或辅助因子进行泛素化和去泛素化，能够介导某些生理和病理过程。泛素化和去泛素化的动态平衡确保染色质处于健康的稳定状态。组蛋白泛素化酶和去泛素化酶通过识别DNA损伤位点、传导信号和招募修复因子等方式参与维持染色质稳态。组蛋白泛素化修饰和去泛素化修饰通过抑制（多数）或促进（少数）基因转录，从而影响基因表达。本综述主要关注组蛋白泛素化修饰和去泛素化修饰与染色质稳态和基因转录的关系，探讨这些过程在发育调控和在某些疾病中的作用，为相关疾病的治疗提供理论依据。 |
| 英文摘要: |
| ABSTRACT: Histone or transcription factors or their co-factors, which are able to carry out the process of some physiological and pathological processes. Dynamic balance between ubiquitination and deubiquitination ensures healthy chromatic homeostasis. Histone ubiquitination and deubiquitination are involved in the maintenance of chromatin homeostasis through identification of DNA damage sites, conduction signals and recruitment of repair factors. Histone ubiquitination and deubiquitination affecting gene expression by inhibiting (majority) or promoting (minority) gene transcription. In this review we focus on the role of histone ubiquitination and deubiquitination in maintaining chromatic homeotasis and gene transcription. |
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