| 刘 坤,姬朝光,闫晓寒,严汉池,刘培源.BTB蛋白结构与功能研究进展[J].,2019,19(7):1367-1373 |
| BTB蛋白结构与功能研究进展 |
| Research Progress on the Structure and Function of BTB Protein Family |
| 投稿时间：2018-05-28 修订日期：2018-06-23 |
| DOI：10.13241/j.cnki.pmb.2019.07.038 |
| 中文关键词: BTB蛋白 蛋白互作 转录调节 泛素化降解 胚胎发育 |
| 英文关键词: BTB domain Protein-protein interaction Transcriptional regulation Ubiquitin-degradation Embryos development |
| 基金项目:国家重点基础研究发展计划（2013CB910602）；国家高技术研究发展计划（2015AA020101）；天津大学自主创新基金项目（2015XRX-0026） |
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| 中文摘要: |
| 摘要：BTB（Broad-complex, Tramtrack, and Bric-a-brac）蛋白家族存在于痘病毒以及几乎所有真核生物中，该类蛋白为多结构域蛋白，最为显著的特征是含有高度保守且能介导蛋白与蛋白间相互作用的BTB结构域。BTB蛋白具有多种功能，其功能特异性取决于BTB蛋白中其他结构域以及它的互作蛋白。BTB蛋白广泛参与转录调节，染色质重组装，细胞骨架调控和泛素化降解等过程，与胚胎发育，器官形成，信号转导以及免疫调节等生理过程密切相关。除此之外，多种疾病如癌症，神经系统和骨骼肌系统疾病等的病理过程也与BTB蛋白相关。本文以蛋白结构为基础总结了该家族的共性规律并重点论述了BTB蛋白在转录调节以及泛素化降解过程中发挥的重要作用，以期为后续研究提供重要参考。 |
| 英文摘要: |
| ABSTRACT: BTB（Broad-complex, Tramtrack, and Bric-a-brac）protein family, existing in poxvirus and almost all eukaryotes, is closely related to embryos development, organ formation, signal transduction, immune regulation and the pathological process of cancer, neurological or musculoskeletal diseases. The typical protein of this family contains multiple domains including evolutionarily conserved BTB domain that plays a role in protein-protein interaction. BTB proteins have diverse functions, ranging from transcription regulation, chromatin reassembly, cytoskeleton regulation to ubiquitin-degradation. Specificity of functions are determined by additional domains present in BTB family proteins, as well as by interaction partners. The article summarized the general rule of the family on the basis of protein structure and elaborated the significant function in the transcriptional regulation and ubiquitin-degradation in order to provide im- portant reference for further study. |
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