| 曹 博,李吉辰,朴松林,赛音乌力吉,刘 冲,赵大勇.PD-L1和CD147在口腔鳞癌中的表达与临床意义[J].,2019,19(7):1293-1296 |
| PD-L1和CD147在口腔鳞癌中的表达与临床意义 |
| Expressions and Clinical Significances of PD-L1 and CD147 in the Oral Squamous Cell Carcinoma |
| 投稿时间：2018-05-29 修订日期：2018-06-24 |
| DOI：10.13241/j.cnki.pmb.2019.07.020 |
| 中文关键词: 口腔鳞癌 免疫共刺激分子PD-L1 细胞外基质蛋白酶诱导因子CD147 免疫组化 |
| 英文关键词: Oral squamous cell carcinoma PD-L1 CD147 Immunohistochemical |
| 基金项目:黑龙江省留学归国科学基金项目(LC2009C09) |
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| 中文摘要: |
| 摘要 目的：探讨口腔鳞癌组织中免疫共刺激分子PD-L1与细胞外基质蛋白酶诱导因子CD147的表达、两者的相关性及临床意义。方法：应用免疫组化技术检测66例口腔鳞癌组织及36例正常口腔黏膜组织中PD-L1和CD147的表达，分析PD-L1、CD147表达的相关性及二者与口腔鳞癌临床病理参数的关系。结果：PD-L1在口腔鳞癌组织中表达阳性率为68.18% (45/66)，正常口腔黏膜组织中表达阳性率仅为16.67%(6/36)；CD147在口腔鳞癌组织中表达阳性率为74.24%(49/66)，明显高于其在正常口腔黏膜组织中的表达13.88%(5/36)。PD-L1和CD147两者在口腔鳞癌组织中阳性表达率与口腔黏膜组织相比均明显升高(P<0.01)。统计学分析显示，PD-L1和CD147在口腔鳞癌组织中的高表达与患者的性别年龄、吸烟史及肿瘤的体积等因素无明显相关，但与TNM分期及鳞癌的组织分化程度紧密相关。口腔鳞癌组织中PD-L1与CD147两者相关性分析r=0.342，P值小于0.01，说明二者的表达呈显著正相关。结论：口腔鳞癌组织中PD-L1与CD147均呈高表达，并且二者的过度表达可能与口腔鳞癌的发生、发展关系密切，合并检测二者可能为OSCC的诊疗及预后指明新的方向，为口腔鳞癌的靶向治疗提供新的靶点。 |
| 英文摘要: |
| ABSTRACT Objective: To study the expressions and clinical significances of PD-L1 and CD147 in the oral squamous cell carcinoma (OSCC). Methods: The expressions of PD-L1 and CD147 were detected by immunohistochemistry method in 66 cases of OSCC patients and 36 cases of controls with normal oral mucosa tissues. The relationship of PD-L1 and CD147 expressions with the clinicopathologic features were analyzed. Results: The postive expressions of PD-L1 and were detected by immunohistochemistry method in 66 cases of OSCC patients and 36 cases of controls with normal oral mucosa tissues. The relationship of PD-L1 and CD147 expressions with the clinicopathologic features were analyzed. The postive expressions of PD-L1 and CD147 in the OSCC(68.18%,74.24%) were signifiacnatly higher than those of in normal oral mucosa tissue (16.67%,13.88%)(P<0.01). The expression of PD-L1 was positively correlated with with the expression of CD147(r=0.342, P<0.01). The high expressions of PD-L1 and CD147 were associated with the differentiation degree and TNM stage, but they were not correlated with the gender, age, smoker and tumor size. Conclusion: The high expression of PD-L1 and CD147 were closely related to the occurrence, development and metastasis of OSCC. Therefore, combined detection of PD-L1 and CD147 might be valuable for the early diagnosis and prognostic prediction of OSCC. It also provides a new target for the treatment of oral squamous carcinoma. |
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