| 陈佳光,龙慧中,李嘉添,王雨晴,刘小华,谢东兴,杨 拓.高尿酸血症人群血清钙与代谢综合征的相关性研究[J].,2019,19(7):1277-1280 |
| 高尿酸血症人群血清钙与代谢综合征的相关性研究 |
| Association between the Serum Calcium Level and Prevalence of Metabolic Syndrome in the Hyperuricemia Patients |
| 投稿时间：2018-10-30 修订日期：2018-11-22 |
| DOI：10.13241/j.cnki.pmb.2019.07.016 |
| 中文关键词: 高尿酸血症 血清钙 代谢综合征 横断面研究 |
| 英文关键词: Hyperuricemia Serum calcium Metabolic syndrome Cross-sectional study |
| 基金项目:国家自然科学基金项目(81802212)；吴阶平医学基金会临床科研专项资助基金课题(320.6750.17258) |
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| 中文摘要: |
| 摘要 目的：探讨血清钙(Calcium，Ca)水平与高尿酸血症(Hyperuricemia，HU)人群发生代谢综合征(Metabolic syndrome，MetS)的相关性。方法：纳入在中南大学湘雅医院健康管理中心进行健康体检的HU患者作为研究对象。通过Beckman Coulter AU 5800全自动生化分析仪检测纳入研究对象的血清Ca水平，根据中国糖尿病学会标准诊断MetS。根据血清Ca水平将研究人群进行四分类，采用Logistic回归模型探讨不同血清Ca水平与MetS患病的相关性。结果：共纳入711例HU患者作为研究对象，Logistic回归模型结果显示：未校正混杂因素时，与第1分类(最低)血清Ca组相比，总人群中第2-4分类血清Ca组MetS患病率比值比和95%可信区间(95% confidence interval，95% CI)分别为1.45 (95% CI: 0.92, 2.29)、1.87 (95% CI: 1.21, 2.89)和1.88 (95% CI: 1.19, 2.95) (趋势检验P=0.003)，校正年龄和性别以及多因素校正后结果无明显变化。性别亚组分析结果显示该相关性只存在于男性亚组，女性亚组中无显著相关性。结论：男性HU人群血清Ca水平与MetS患病呈正相关，可能为MetS患病的危险因素，适当降低Ca的摄入可能有助于男性HU人群MetS的防治，而女性HU人群中血清Ca水平与MetS患病不相关。 |
| 英文摘要: |
| ABSTRACT Objective: To examine the association between serum calcium (Ca) and prevalence of metabolic syndrome (MetS) in the hyperuricemia (HU) patients. Methods: This study was conducted in the Department of Health Examination Center, Xiangya Hospital, Central South University, and HU patients were included. Serum Ca was measured on a Beckman Coulter AU 5800 system, and MetS was diagnosed according to the Chinese Diabetes Society criteria. The serum Ca concentration was classified into four categories. Results: 711 HU patients were included finally. Compared with the lowest quintile, the unadjusted odds ratios and 95% confidence inter- val (95% CI) for MetS were 1.45 (95% CI: 0.92, 2.29), 1.87 (95% CI: 1.21, 2.89) and 1.88 (95% CI: 1.19, 2.95) from the second to fourth quintiles of serum Ca, respectively (P value for trend =0.003). The findings were not materially altered by adjustment for more potential confounders. However, the positive association between serum Ca and prevalence of MetS only existed in men but not in women. Conclusion: The findings of the present study indicated that there was a positive association between the level of serum Ca and MetS in the male HU patients, and high level of serum Ca may be a risk factor for developing MetS in this population. Therefore, moderate re- striction of Ca intake may contribute to the prevention and treatment of MetS in male HU patients. No significant association was found between serum Ca level and prevalence of MetS in the female population. |
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