| 陈晓萌,高 琰,王克迪,宁 炜,苏建荣.白细胞介素-1家族细胞因子水平与非酒精性脂肪性肝病及非酒精性脂肪性肝炎病程进展的相关性分析[J].,2019,19(5):886-889 |
| 白细胞介素-1家族细胞因子水平与非酒精性脂肪性肝病及非酒精性脂肪性肝炎病程进展的相关性分析 |
| Analysis of Correlation Between IL-1 Family Cytokines and Progression of NAFLD and NASH |
| 投稿时间：2018-12-08 修订日期：2018-12-30 |
| DOI：10.13241/j.cnki.pmb.2019.05.020 |
| 中文关键词: 非酒精性脂肪性肝病 非酒精性脂肪性肝炎 IL-1RA IL-1β IL-18 相关性 |
| 英文关键词: Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis IL-1RA IL-1β IL-18 Correlation |
| 基金项目:北京市科技计划项目（201502127634） |
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| 中文摘要: |
| 摘要 目的：探讨并分析血清白细胞介素-1受体拮抗剂（IL-1RA）、白细胞介素-1β（IL-1β）和白细胞介素-18（IL-18）水平与非酒精性脂肪性肝病（NAFLD）及非酒精性脂肪性肝炎（NASH）病程进展的相关性。方法：选取我院收治的54例NAFLD患者为研究对象，根据NAFLD活动度积分（NAS）积分分为非NASH组和NASH组；另选取同期来我院体检的30例健康人群作为对照组。比较各组临床特征及相关生化指标，分析血清IL-1RA、IL-1β、IL-18水平与各生化指标及NAS积分的相关性。结果：NAFLD患者体重指数（BMI）、丙氨酸转氨酶（ALT）、谷氨酰转肽酶（GGT）、甘油三酯（TG）、空腹血糖（GLU）、IL-1β和IL-18水平均显著高于对照组（P＜0.05），血清IL-1RA、高密度脂蛋白（HDL）低于对照组（P＜0.05），其中NASH组患者ALT、AST、GGT、IL-1β和IL-18水平高于非NASH组（P＜0.05），非NASH组血清IL-1RA水平高于NASH组（P＜0.05）。相关性分析结果显示，相关性分析结果显示，血清IL-1RA水平与NAS积分呈负相关（P＜0.05），与BMI、ALT、GGT、TG、低密度脂蛋白（LDL）呈正相关（P＜0.05），IL-1β和IL-18水平与NAS评分呈正相关（P＜0.05）。结论：血清IL-1RA、IL-1β和IL-18水平与NAFLD及NASH患者病情进展有关，可反应其病变严重程度，血清IL-1RA后期持续分泌不足使其对炎症的抑制作用减弱可能是NAFLD患者病情进展至NASH的重要原因。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate and analyze the correlation between serum levels of interleukin-1RA(IL-1RA), inter- leukin-1β (IL-1β), interleukin-18 (IL-18) and the progression of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steato- hepatitis (NASH). Methods: 54 patients with NAFLD in our hospital were selected as the research object, According to NAFLD activity score (NAS), they were divided into non-NASH group and NASH group. Another 30 healthy people who came to our hospital for physi- cal examination during the same period were selected as the control group. The correlation between serum IL-1RA, IL-1β, IL-18 levels and biochemical indexes and NAS scores was analyzed. Results: The body mass index(BMI), alanine aminotransferase(ALT), glutamyl- transferase(GGT), triglyceride(TG), fasting blood glucose (GLU), IL-1β and IL-18 levels in NAFLD patients were significantly higher than those in the control group(P<0.05), and the serum levels of IL-1RA, high density lipoprotein(HDL) were lower than those in the con- trol group(P<0.05). The levels of ALT, AST, GGT, IL-1β and IL-18 in NASH patients were higher than those in non-NASH patients. The serum level of IL-1RA in non-NASH group was higher than that in NASH group(P<0.05). The results of correlation analysis showed that serum IL-1RA level was negatively correlated with NAS score (P<0.05), positively correlated with BMI, ALT, GGT, TG and low density lipoprotein (LDL)(P<0.05), and the levels of IL-1β and IL-18 were positively correlated with NAS scores (P<0.05). Conclusion: Serum levels of IL-1RA, IL-1β and IL-18 are related to the progression of NAFLD and NASH, and can reflect the severity of NAFLD and NASH. Inadequate secretion of IL-1RA in late stage may be an important reason for the progression of NAFLD to NASH. |
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