| 邓宏炬,刘振鹏,贾安平,梁秀兰,蔡怀阳,陈春妮.门冬氨酸鸟氨酸注射液联合乳果糖对肝性脑病患者肝功能和炎性因子水平的影响[J].,2019,19(4):767-771 |
| 门冬氨酸鸟氨酸注射液联合乳果糖对肝性脑病患者肝功能和炎性因子水平的影响 |
| Effects of Ornithine Aspartate Injection Combined with Lactulose on Liver Function and Inflammatory Factors in Patients with Hepatic Encephalopathy |
| 投稿时间：2018-08-08 修订日期：2018-08-31 |
| DOI：10.13241/j.cnki.pmb.2019.04.036 |
| 中文关键词: 门冬氨酸鸟氨酸注射液 乳果糖 肝性脑病 肝功能 炎性因子 疗效 |
| 英文关键词: Ornithine Aspartate Injection Lactulose Hepatic encephalopathy Liver function Inflammatory factors Curative effect |
| 基金项目:广西壮族自治区医药卫生科研基金项目（Z2013235） |
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| 中文摘要: |
| 摘要 目的：探讨门冬氨酸鸟氨酸注射液联合乳果糖对肝性脑病（HE）患者肝功能和炎性因子水平的影响。方法：选取2014年1月~2018年1月期间广西医科大学附属柳铁中心医院收治的HE患者120例为研究对象。根据数字表法将患者随机分为对照组（n=60）和研究组（n=60），对照组给予乳果糖治疗，研究组在对照组基础上联合门冬氨酸鸟氨酸注射液治疗，两组患者均持续治疗14 d。比较两组患者治疗后临床疗效，以及两组患者治疗前后肝功能、炎性因子水平、血尿淀粉酶（AMY）、血氨浓度。记录两组患者治疗期间不良反应发生情况。结果：研究组患者治疗后总有效率为91.67%（55/60），显著高于对照组患者的63.33%（38/60）（P<0.05）。两组患者治疗后谷丙转氨酶（ALT）、总胆红素（TBIL）、天冬氨酸转氨酶（AST）水平均较治疗前降低，且研究组低于对照组（P<0.05）。两组患者治疗后血清白介素-6（IL-6）、白介素-8（IL-8）、白介素-1（IL-1）、肿瘤坏死因子-α（TNF-α）、超敏C反应蛋白（hs-CRP）水平均较治疗前降低，且研究组低于对照组（P<0.05）。两组患者治疗后血AMY、尿AMY、血氨浓度均较治疗前降低，且研究组血氨浓度低于对照组（P<0.05），但研究组血AMY、尿AMY与对照组比较差异无统计学意义（P>0.05）。两组患者治疗期间不良反应率比较差异无统计学意义（P>0.05）。结论：门冬氨酸鸟氨酸注射液联合乳果糖治疗HE患者安全有效，可有效改善患者肝功能，减轻炎性应激，降低血尿AMY、血氨浓度，具有一定的临床应用价值。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of Ornithine Aspartate Injection combined with lactulose on liver function and in- flammatory factors in patients with hepatic encephalopathy (HE). Methods: 120 patients with HE who were admitted to Liutie Central Hospital Affiliated to Guangxi Medical University from January 2014 to January 2018 were selected as subjects. Patients were randomly divided into control group (n=60) and study group (n=60) according to the number table method. The control group was treated with lac- tulose. The study group was treated with Ornithine Aspartate Injection on the basis of the control group. Two groups of patients were treated for 14d continuously. The clinical efficacy, liver function, inflammatory factors, blood and urine amylase (AMY) and serum ammonia levels were compared between the two groups before treatment and after treatment. The adverse reactions of the two groups during treatment were recorded. Results: The total effective rate was 91.67% (55/60) in the study group, which was significantly higher than 63.33%(38/60) in the control group (P<0.05). The levels of alanine aminotransferase (ALT), total bilirubin (TBIL) and aspartate amino- transferase(AST) in the two groups after treatment were lower than those before treatment, and the study group was lower than the con- trol group(P<0.05). The serum levels of interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-1 (IL-1), tumor necrosis factor-α (TNF-α) and hypersensitive C-reactive protein (hs-CRP) in the two groups after treatment were lower than those before treatment, and the study group was lower than the control group (P<0.05). The blood AMY, urine AMY, blood ammonia concentration in the two groups after treatment were lower than before treatment, the blood ammonia concentration in the study group was lower than that in the control group (P<0.05). However,there was no significant difference in blood AMY and urine AMY between the study group and the control group (P>0.05). There was no significant difference in adverse reactions between the two groups during treatment(P>0.05). Conclusion: Ornithine Aspartate Injection combined with lactulose is effective in the treatment of patients with HE. It can effectively improve the liver function, relieve inflammatory stress, reduce blood urine AMY and blood ammonia concentration, and it has a certain clinical value. |
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