| 钟克涛,静广平,田 兵,俞 晴,王海涛,胡腾龙.CXXC4、EZH2在口腔鳞状细胞癌中表达及临床意义[J].,2019,19(4):676-679 |
| CXXC4、EZH2在口腔鳞状细胞癌中表达及临床意义 |
| Expressions and Clinical Significances of CXXC4 and EZH2 in the Oral Squamous Cell Carcinoma |
| 投稿时间：2018-04-08 |
| DOI：10.13241/j.cnki.pmb.2019.04.016 |
| 中文关键词: 口腔鳞状细胞癌 CXXC4 EZH2 |
| 英文关键词: Oral Squamous Cell Carcinoma CXXC4 EZH2 |
| 基金项目:黑龙江省应用技术与开发计划项目（GA14C101-10） |
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| 中文摘要: |
| 摘要 目的：探讨口腔鳞状细胞癌(Oral Squamous Cell Carcinoma，OSCC)中CXXC指蛋白4(CXXC finger protein 4，CXXC4)与Zeste基因增强子同源物2(Enhancer of zeste homolog 2，EZH2)的表达、相关性及与临床病理特征之间的关系，为OSCC的早期诊断、治疗、判断预后及预防等提供参考依据。方法：采用免疫组织化学S-P法检测CXXC4蛋白及EZH2蛋白在60例口腔鳞状细胞癌组织及20例非肿瘤患者正常口腔黏膜组织中的表达情况，分析二者与口腔鳞状细胞癌临床病理特征的相关性。结果：口腔鳞状细胞癌组织中CXXC4蛋白的表达率为35.0% (21/60)，明显低于正常口腔黏膜组织的60.0% (12/20)(P＜0.05)；口腔鳞状细胞癌中EZH2蛋白的表达率为70.0% (42/60)，高于正常口腔黏膜组织的25% (5/20)(P＜0.05)。CXXC4蛋白与EZH2蛋白的表达与口腔鳞状细胞癌的病理分化程度、TNM分期及淋巴结转移等密切相关(P＜0.05)，而与年龄、性别及肿瘤直径大小等无关。CXXC4蛋白与EZH2蛋白在OSCC中表达呈负相关(r=-0.511，P＜0.001)。结论：CXXC4蛋白的表达下调或缺失以及EZH2蛋白的表达上调或过表达与口腔鳞状细胞癌的发生、发展及侵袭转移有关，可能作为口腔鳞状细胞癌预后预测的参考指标。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the expressions of CXXC finger protein 4(CXXC4) and the enhancer of zeste homolog 2(EZH2) in the oral squamous cell carcinoma(OSCC)and explore the correlation with the clinicopathologic features. Methods: The expres- sion of CXXC4 and EZH2 were measured using immunohistochemistry in 60 cases of oral squamous cell carcinoma and 20 cases of nor- mal oral tissues. Statistical analysis was used to determine the correlation between their expression and clinicopathologic parameters. Results: The positive expression rate of CXXC4 was 35.0% (21/60) in OSCC tissue，which was lower than that of 60.0% (12/20) in the normal oral tissues(P＜0.05). However, the positive expression rate of EZH2 was 70.0% (42/60) in OSCC tissues, which was significantly higher than that of 25.0% (5/20) in the normal oral tissues(P＜0.05). The expression of CXXC4 and EZH2 were significantly correlated with the differentiation of tumor, TNM staging and the development of lymph node metastasis(P＜0.05). There was a negative correlation be- tween the expression of CXXC4 and EZH2 in oral squamous cell carcinoma(r=-0.511, P＜0.001). Conclusion: The expression of CXXC4 and EZH2 may play an important role in the initiation and development of OSCC. The low expression of CXXC4 and high ex- pression of EZH2 may promote the invasion and metastasis of OSCC. |
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