| 崔胜楠,周智辉,李佳恬,白英英,田亚宁,翟冬芝,董昌虎,李 宏.DGKs与肿瘤的关系及作用机制研究进展[J].,2019,19(3):596-600 |
| DGKs与肿瘤的关系及作用机制研究进展 |
| The Relationship and Mechanism between DGKs and Tumor |
| 投稿时间：2018-03-27 修订日期：2018-04-23 |
| DOI：10.13241/j.cnki.pmb.2019.03.047 |
| 中文关键词: 二酰甘油激酶家族 肿瘤 免疫 |
| 英文关键词: Diacylglycerol kinase family Tumor Immune |
| 基金项目:陕西省中医药管理局科研基金项目（JCMS041） |
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| 中文摘要: |
| 摘要：二酰甘油激酶家族（DGKs）通过调节两种脂质信号（甘油二酯和磷脂酸）之间的平衡在信号转导中起重要作用。哺乳动物的DGKs作为由十种亚型构成的蛋白质家族，根据它们的结构特征将其分为五型。这些亚型可以通过已知和/或预测功能的各种调节结构域，清楚地表明其不同的功能和调节机制。目前大量的研究表明DGKs可通过调节机体的免疫功能及调控多种肿瘤相关信号通路从而对肿瘤细胞的增殖、凋亡、转移起作用。本文就DGKs与肿瘤之间关系及作用机制进行综述，以期为肿瘤的治疗提供新的思路和方法。 |
| 英文摘要: |
| ABSTRACT: Diacylglycerol kinases (DGKs) plays an important role in signal transduction by regulating the balance of two lipid signals which are iglycerides and phosphatidic acids. Mammalian DGKs, as a protein family, are conposed of ten subtypes, and are divided into five types based on the structural characteristics of each subtypes. These subtypes can clearly indicate their different functions and regulatory mechanisms through various regulatory domains known. At present, a large number of studies have shown that DGKs play a role in the proliferation, apoptosis and metastasis of tumor cells by regulating the body's immune function and regulating a variety of tumor-related signaling pathways. This article reviews the relationships and mechanisms between DGKs and tumor. We hope this reviews can provide new ideas and methods for tumor treatment. |
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