文章摘要
陈 明,裴 静,孔祥锋,高 华,朱志华.急性脑梗死患者Hcy、D-二聚体检测及其危险因素分析[J].,2019,19(3):515-518
急性脑梗死患者Hcy、D-二聚体检测及其危险因素分析
Detection of serum Hcy and D-dimer Levels of Patients with Acute Cerebral Infarction and Analysis of Risk Factors
投稿时间:2018-04-30  修订日期:2018-05-26
DOI:10.13241/j.cnki.pmb.2019.03.027
中文关键词: 急性脑梗死  同型半胱氨酸  D-二聚体  危险因素
英文关键词: Acute cerebral infarction  Hcy  D- two dimer  Risk factors
基金项目:新疆维吾尔自治区自然科学基金项目(2015211C164)
作者单位E-mail
陈 明 新疆医科大学第五附属医院神经内科 新疆 乌鲁木齐 830000 chenming2358@163.com 
裴 静 新疆医科大学第五附属医院神经内科 新疆 乌鲁木齐 830000  
孔祥锋 新疆医科大学第五附属医院神经内科 新疆 乌鲁木齐 830000  
高 华 新疆医科大学第五附属医院神经内科 新疆 乌鲁木齐 830000  
朱志华 新疆医科大学第五附属医院神经内科 新疆 乌鲁木齐 830000  
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中文摘要:
      摘要 目的:探讨急性脑梗死患者同型半胱氨酸(Hcy)、D-二聚体水平的变化及急性脑梗死的危险因素。方法:选取2016年12月至2017年5月本院收治的100例急性脑死患者作为研究对象,依据急性脑梗死症状发生至96 h神经功能缺失症状是否有进行性加重分为进展组(45例)和非进展组(55例),另选取同期来院体检的非急性脑梗死者100例作为对照组。比较组间Hcy、D-二聚体水平,并分析急性脑梗死发生的危险因素。结果:两组间高血压史、糖尿病史、TG、TC、LDL、HDL水平比较差异有统计学意义(P<0.05)。与对照组相比,观察组血清Hcy及D-二聚体水平均显著升高,且进展组水平显著高于非进展组,差异有统计学意义(P<0.05)。多因素Logistic 回归分析结果显示高血压史、糖尿病史、TG、LDL、Hcy、D-二聚体是急性脑梗死的危险因素,HDL是保护因素(P<0.05)。结论:急性脑梗死患者存在Hcy、D-二聚体水平异常,高血压史、糖尿病史、血脂异常、Hcy、D-二聚体与急性脑梗死发生有关。
英文摘要:
      ABSTRACT Objective: To investigate the changes of plasma homocysteine (Hcy), D-dimer level and risk factors of acute cerebral infarction in patients with acute cerebral infarction. Methods: A total of 100 cases of acute cerebral infarction patients were selected from December 2016 to May 2017 in our hospital as the research object, on the basis of symptoms of acute cerebral infarction and 96 h neurological deficits are progressively divided into progress group (45 cases) and non progressive group (55 cases), and the other selected hospital examination of non acute cerebral infarction in 100 cases as control group. The levels of Hcy and D-dimer were compared between groups, and the risk factors of acute cerebral infarction were analyzed. Results: Univariate analysis showed that there were significant differences in the history of hypertension, history of diabetes mellitus, TG, TC, LDL and HDL between the two groups (P<0.05); Compared with the control group, the levels of serum Hcy and D-dimer in the observation group were significantly increased, and the level of the progression group was significantly higher than that of the non progressive group, the difference was statistically significant (P<0.05). Multivariate Logistic regression analysis showed that history of hypertension, history of diabetes mellitus, TG, LDL, Hcy and D-dimer were risk factors for acute cerebral infarction, and HDL was a protective factor (P<0.05). Conclusion: Abnormal levels of Hcy and D-dimer were found in patients with acute cerebral infarction. The history of hypertension, history of diabetes mellitus, dyslipidemia, Hcy and D-dimer were related to the occurrence of acute cerebral infarction, and the monitoring of these indicators was of great value for the disease prevention and treatment.
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